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Development and validation of a sensor prototype for near-infrared imaging of the newborn brain


Ahnen, Linda; Stachel, Helene; Kleiser, Stefan; Hagmann, Cornelia; Jiang, Jingjing; Kalyanov, Alexander; Lindner, Scott; Wolf, Martin; Sanchez, Salvador (2017). Development and validation of a sensor prototype for near-infrared imaging of the newborn brain. In: LaManna, J C; Halpern, H J; Harrison, D K; Epel, B. Adv Exp Med Biol. New York: Springer, 163-168.

Abstract

Imaging brain oxygenation is crucial for preventing brain lesions in preterm infants. Our aim is to build and validate a near-infrared optical tomography (NIROT) sensor for the head of neonates. This sensor, combined with an optoacoustic device, will enable quantitative monitoring of the structural and functional information of the brain. Since the head of preterm infants is small and fragile great care must be taken to produce a comfortable and compact device in which a sufficient number of light sources and detectors can be implemented. Here we demonstrate our first prototype. Heterogeneous silicone phantoms were produced to validate the prototype's data acquisition, data processing, and image reconstruction. Reconstructed optical properties agree well with the target values. The mechanical performance of the new NIROT sensor prototype confirms its suitability for the clinical application.

Abstract

Imaging brain oxygenation is crucial for preventing brain lesions in preterm infants. Our aim is to build and validate a near-infrared optical tomography (NIROT) sensor for the head of neonates. This sensor, combined with an optoacoustic device, will enable quantitative monitoring of the structural and functional information of the brain. Since the head of preterm infants is small and fragile great care must be taken to produce a comfortable and compact device in which a sufficient number of light sources and detectors can be implemented. Here we demonstrate our first prototype. Heterogeneous silicone phantoms were produced to validate the prototype's data acquisition, data processing, and image reconstruction. Reconstructed optical properties agree well with the target values. The mechanical performance of the new NIROT sensor prototype confirms its suitability for the clinical application.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > General Biochemistry, Genetics and Molecular Biology
Language:English
Date:July 2017
Deposited On:10 Jan 2018 15:34
Last Modified:28 Jul 2020 12:33
Publisher:Springer
Series Name:Advances in Experimental Medicine and Biology
Number:977
ISSN:0065-2598
ISBN:978-1-4614-4771-9
Additional Information:This is a post-peer-review, pre-copyedit version of an article published in Advances in Experimental Medicine and Biology. The final authenticated version is available online at: https:/10.1007/978-3-319-55231-6_22
OA Status:Green
Publisher DOI:https://doi.org/10.1007/978-3-319-55231-6_22
Official URL:https://link.springer.com/chapter/10.1007%2F978-3-319-55231-6_22
PubMed ID:28685441

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