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Role of Regulatory Cells in Oral Tolerance


Wawrzyniak, Marcin; O'Mahony, Liam; Akdis, Mübeccel (2017). Role of Regulatory Cells in Oral Tolerance. Allergy, Asthma & Immunology Research, 9(2):107.

Abstract

The immune system is continuously exposed to great amounts of different antigens from both food and intestinal microbes. Immune tolerance to these antigens is very important for intestinal and systemic immune homeostasis. Oral tolerance is a specific type of peripheral tolerance induced by exposure to antigen via the oral route. Investigations on the role of intestinal immune system in preventing hypersensitivity reactions to innocuous dietary and microbial antigens have been intensively performed during the last 2 decades. In this review article, we discuss how food allergens are recognized by the intestinal immune system and draw attention to the role of regulatory T (Treg) and B (Breg) cells in the establishment of oral tolerance and tolerogenic features of intestinal dendritic cells. We also emphasize the potential role of tonsils in oral tolerance induction because of their anatomical location, cellular composition, and possible usage to develop novel ways of specific immunotherapy for the treatment of allergic diseases.

Abstract

The immune system is continuously exposed to great amounts of different antigens from both food and intestinal microbes. Immune tolerance to these antigens is very important for intestinal and systemic immune homeostasis. Oral tolerance is a specific type of peripheral tolerance induced by exposure to antigen via the oral route. Investigations on the role of intestinal immune system in preventing hypersensitivity reactions to innocuous dietary and microbial antigens have been intensively performed during the last 2 decades. In this review article, we discuss how food allergens are recognized by the intestinal immune system and draw attention to the role of regulatory T (Treg) and B (Breg) cells in the establishment of oral tolerance and tolerogenic features of intestinal dendritic cells. We also emphasize the potential role of tonsils in oral tolerance induction because of their anatomical location, cellular composition, and possible usage to develop novel ways of specific immunotherapy for the treatment of allergic diseases.

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Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Food allergy, oral tolerance, regulatory cells, dendritic cells, Tregs
Language:English
Date:March 2017
Deposited On:26 Jan 2018 08:48
Last Modified:19 Aug 2018 13:12
Publisher:The Korean Academy of Asthma Allergy and Clinical Immunology
ISSN:2092-7355
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.4168/aair.2017.9.2.107
Project Information:
  • : FunderFP7
  • : Grant ID260895
  • : Project TitlePREDICTA - Post-infectious immune reprogramming and its association with persistence and chronicity of respiratory allergic diseases
  • : FunderFP7
  • : Grant ID261357
  • : Project TitleMEDALL - Mechanisms of the Development of ALLergy

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