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Immune regulation by histamine and histamine-secreting bacteria


Barcik, Weronika; Wawrzyniak, Marcin; Akdis, Cezmi A; O’Mahony, Liam (2017). Immune regulation by histamine and histamine-secreting bacteria. Current Opinion in Immunology, 48:108-113.

Abstract

Histamine is a biogenic amine with extensive effects on many immune cell types. Histamine and its four receptors (H1R-H4R) represent a complex system of immunoregulation with distinct effects dependent on receptor subtypes and their differential expression. In addition to mammalian cells, bacteria can also secrete histamine and the influence of microbiota-derived histamine on host immunological processes is only beginning to be described. However, it is clear that histamine-secreting microbes are present within the human gut microbiota and their levels are increased in asthma patients. Additional studies are required to fully understand the complex regulatory interactions between histamine and the host immune response to everyday microbial and environmental challenges.

Abstract

Histamine is a biogenic amine with extensive effects on many immune cell types. Histamine and its four receptors (H1R-H4R) represent a complex system of immunoregulation with distinct effects dependent on receptor subtypes and their differential expression. In addition to mammalian cells, bacteria can also secrete histamine and the influence of microbiota-derived histamine on host immunological processes is only beginning to be described. However, it is clear that histamine-secreting microbes are present within the human gut microbiota and their levels are increased in asthma patients. Additional studies are required to fully understand the complex regulatory interactions between histamine and the host immune response to everyday microbial and environmental challenges.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:October 2017
Deposited On:26 Jan 2018 10:17
Last Modified:19 Aug 2018 13:12
Publisher:Elsevier
ISSN:0952-7915
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.coi.2017.08.011
PubMed ID:28923468
Project Information:
  • : FunderSNSF
  • : Grant ID310030_144219
  • : Project TitleMicrobiota-Derived Histamine - Relevance to Mucosal Immune Homeostasis
  • : FunderSNSF
  • : Grant IDCRSII3_154488
  • : Project TitleThe Microbe-Host Interface: Molecular Mechanisms Mediating Protective and Pathological Innate and Adaptive Immune Responses within the Gut

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