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Gauging circadian variation in ketamine metabolism by real-time breath analysis


Martinez-Lozano Sinues, P; Kohler, M; Brown, S A; Zenobi, R; Dallmann, R (2017). Gauging circadian variation in ketamine metabolism by real-time breath analysis. Chemical Communications, 53(14):2264-2267.

Abstract

The time-of-day of drug application is an important factor in maximizing efficacy and minimizing toxicity. Real-time in vivo mass spectrometric breath analysis of mice was deployed to investigate time-of-day variation in ketamine metabolism. Different production rates of ketamine metabolites, including the recently described anti-depressant hydroxynorketamine, were found in opposite circadian phases. Thus, breath analysis has potential as a rapid and 3Rs (Replacement, Reduction and Refinement) conforming screening method to estimate the time-dependence of drug metabolism.

Abstract

The time-of-day of drug application is an important factor in maximizing efficacy and minimizing toxicity. Real-time in vivo mass spectrometric breath analysis of mice was deployed to investigate time-of-day variation in ketamine metabolism. Different production rates of ketamine metabolites, including the recently described anti-depressant hydroxynorketamine, were found in opposite circadian phases. Thus, breath analysis has potential as a rapid and 3Rs (Replacement, Reduction and Refinement) conforming screening method to estimate the time-dependence of drug metabolism.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:14 February 2017
Deposited On:23 Jan 2018 15:38
Last Modified:19 Aug 2018 13:15
Publisher:Royal Society of Chemistry
ISSN:1359-7345
OA Status:Closed
Publisher DOI:https://doi.org/10.1039/c6cc09061c
PubMed ID:28150005
Project Information:
  • : FunderFP7
  • : Grant ID276860
  • : Project TitleCMPTIMSMS - Cancer metabolic profiling through ion mobility and mass spectrometric-based methods

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