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Brain stimulation over the frontopolar cortex enhances motivation to exert effort for reward


Soutschek, Alexander; Kang, Pyungwon; Ruff, Christian C; Hare, Todd A; Tobler, Philippe N (2018). Brain stimulation over the frontopolar cortex enhances motivation to exert effort for reward. Biological Psychiatry, 84(1):38-45.

Abstract

Background: Loss of motivation is a characteristic feature of several psychiatric and neurological disorders. However, the neural mechanisms underlying human motivation are far from being understood. Here, we investigate the role that the frontopolar cortex (FPC) plays in motivating cognitive and physical effort exertion by computing subjective effort equivalents.
Methods: We manipulated neural processing with transcranial direct current stimulation targeting the FPC while 141 healthy participants decided whether or not to engage in cognitive or physical effort to obtain rewards.
Results: We found that brain stimulation targeting the FPC increased the amount of both types of effort participants were willing to exert for rewards.
Conclusions: Our findings provide important insights into the neural mechanisms involved in motivating effortful behavior. Moreover, they suggest that considering the motivation-related activity of the FPC could facilitate the development of treatments for the loss of motivation commonly seen in psychiatric and other neurological disorders.

Abstract

Background: Loss of motivation is a characteristic feature of several psychiatric and neurological disorders. However, the neural mechanisms underlying human motivation are far from being understood. Here, we investigate the role that the frontopolar cortex (FPC) plays in motivating cognitive and physical effort exertion by computing subjective effort equivalents.
Methods: We manipulated neural processing with transcranial direct current stimulation targeting the FPC while 141 healthy participants decided whether or not to engage in cognitive or physical effort to obtain rewards.
Results: We found that brain stimulation targeting the FPC increased the amount of both types of effort participants were willing to exert for rewards.
Conclusions: Our findings provide important insights into the neural mechanisms involved in motivating effortful behavior. Moreover, they suggest that considering the motivation-related activity of the FPC could facilitate the development of treatments for the loss of motivation commonly seen in psychiatric and other neurological disorders.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
Dewey Decimal Classification:330 Economics
Uncontrolled Keywords:Cognitive effort, decision making, frontal pole, physical effort, reward, tDCS
Language:English
Date:2018
Deposited On:23 Jan 2018 20:09
Last Modified:24 Sep 2019 23:09
Publisher:Elsevier
ISSN:0006-3223
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.biopsych.2017.11.007
PubMed ID:29275840
Project Information:
  • : FunderFP7
  • : Grant ID249812
  • : Project TitleTWENTIES - Transmission system operation with large penetration of Wind and other renewable Electricity sources in Networks by means of innovative Tools and Integrated Energy Solutions.
  • : FunderSNSF
  • : Grant ID100014_165884
  • : Project TitleThe role of dopamine in value-based decision making
  • : FunderSNSF
  • : Grant IDPP00P1_150739
  • : Project TitleThe neural basis of economic and moral utility
  • : FunderSNSF
  • : Grant ID320030_143443
  • : Project TitleNeural networks promoting strategies for long-term success over immediate gain in reward learning and decision making
  • : FunderSNSF
  • : Grant IDCRSII3_141965
  • : Project TitleNeuroeconomics of value-based decision making

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