Header

UZH-Logo

Maintenance Infos

Aktuelle Indikationen zur operativen Therapie beim kleinzelligen Lungenkarzinom


Jungraithmayr, Wolfgang (2017). Aktuelle Indikationen zur operativen Therapie beim kleinzelligen Lungenkarzinom. Zentralblatt für Chirurgie, 142(S 01):S44-S50.

Abstract

Small cell lung cancer (SCLC) is characterised by an aggressive and rapid growth, with a tendency towards early metastatic spread. It has one of the worst prognoses of all malignancies. Though radio-chemotherapy is still considered the mainstay of therapy due to its high sensitivity, increasing evidence, supported by a number of retrospective analyses and large case series, suggests that surgery may play a significant role in the treatment of SCLC within a multimodality treatment concept. In this context, surgery can provide overall survival benefit and improve local control in selected cases. Currently, an operation can be recommended if the SCLC manifests as a single peripheral node, in early cancer stages (T1 - 2, N0, M0), in cases of mixed histological tumour types but also in selected cases in chemotherapy-resistant tumors. In the light of the current availability of immunotherapy by checkpoint inhibitors, resection of SCLC should also be considered on the basis of the expression of checkpoint receptors that might have relevant impact on therapy and prognosis of the course of SCLC. In order to fulfil the above-mentioned criteria and to provide a higher level of evidence and to develop guidelines, randomised controlled trials need to be performed.

Abstract

Small cell lung cancer (SCLC) is characterised by an aggressive and rapid growth, with a tendency towards early metastatic spread. It has one of the worst prognoses of all malignancies. Though radio-chemotherapy is still considered the mainstay of therapy due to its high sensitivity, increasing evidence, supported by a number of retrospective analyses and large case series, suggests that surgery may play a significant role in the treatment of SCLC within a multimodality treatment concept. In this context, surgery can provide overall survival benefit and improve local control in selected cases. Currently, an operation can be recommended if the SCLC manifests as a single peripheral node, in early cancer stages (T1 - 2, N0, M0), in cases of mixed histological tumour types but also in selected cases in chemotherapy-resistant tumors. In the light of the current availability of immunotherapy by checkpoint inhibitors, resection of SCLC should also be considered on the basis of the expression of checkpoint receptors that might have relevant impact on therapy and prognosis of the course of SCLC. In order to fulfil the above-mentioned criteria and to provide a higher level of evidence and to develop guidelines, randomised controlled trials need to be performed.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Additional indexing

Other titles:Current Indications for Surgery in Small Cell Lung Cancer
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Thoracic Surgery
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:September 2017
Deposited On:01 Feb 2018 08:15
Last Modified:19 Feb 2018 10:48
Publisher:Georg Thieme Verlag
ISSN:0044-409X
OA Status:Closed
Publisher DOI:https://doi.org/10.1055/s-0043-115642
PubMed ID:28772312

Download

Full text not available from this repository.
View at publisher

Get full-text in a library