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Uterine and placental expression of HPGD in cows during pregnancy and release of fetal membranes


von Hof, Jessica. Uterine and placental expression of HPGD in cows during pregnancy and release of fetal membranes. 2017, University of Zurich, Vetsuisse Faculty.

Abstract

15-hydroxyprostaglandin dehydrogenase (HPGD) plays a key role in prostaglandins (PGs) catabolism. Its expression and activity appear to be regulated by progesterone (P4). We investigated the HPGD mRNA-expression and protein localization in placentomes and interplacental uterine sites throughout gestation (Study I), and after fetal membranes retention (RFM) compared with normally delivered fetal membranes (DFM) (Study II). Furthermore, we analyzed the influence of aglepristone (AP), dexamethasone (GC) or cloprostenol (CP), on HPGD expression in bovine placentomes (Study III). Tissues from late gestation (D272) and at normal term (NT) served as controls. HPGD was highest in all sites at the beginning of pregnancy and at (NT). Following induced parturition HPGD was lower after (AP) and (GC) compared with (NT), and was similar in RFM and DFM. Placentomes stained primarily in fetal compartments; interplacentomal signals were observed in glandular and luminal epithelium. Results indicate that HPGD may play a role during establishment and termination of gestation.

Abstract

15-hydroxyprostaglandin dehydrogenase (HPGD) plays a key role in prostaglandins (PGs) catabolism. Its expression and activity appear to be regulated by progesterone (P4). We investigated the HPGD mRNA-expression and protein localization in placentomes and interplacental uterine sites throughout gestation (Study I), and after fetal membranes retention (RFM) compared with normally delivered fetal membranes (DFM) (Study II). Furthermore, we analyzed the influence of aglepristone (AP), dexamethasone (GC) or cloprostenol (CP), on HPGD expression in bovine placentomes (Study III). Tissues from late gestation (D272) and at normal term (NT) served as controls. HPGD was highest in all sites at the beginning of pregnancy and at (NT). Following induced parturition HPGD was lower after (AP) and (GC) compared with (NT), and was similar in RFM and DFM. Placentomes stained primarily in fetal compartments; interplacentomal signals were observed in glandular and luminal epithelium. Results indicate that HPGD may play a role during establishment and termination of gestation.

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Additional indexing

Item Type:Dissertation (monographical)
Referees:Kowalewski Mariusz P, Boos Alois
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Anatomy
UZH Dissertations
Dewey Decimal Classification:630 Agriculture
Uncontrolled Keywords:Cattle, Pregnancy, Placenta, Hydroxyprostaglandin Dehydrogenases
Language:English
Place of Publication:Zürich
Date:2017
Deposited On:26 Jan 2018 17:23
Last Modified:07 Apr 2020 07:07
Number of Pages:13
Additional Information:Publiziert in: Prostaglandins and other lipid mediators 2017 Jan;128-129:17-26., doi: 10.1016/j.prostaglandins.2016.12.003
OA Status:Closed
Related URLs:https://www.recherche-portal.ch/permalink/f/5u2s2l/ebi01_prod010920757 (Library Catalogue)

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