Header

UZH-Logo

Maintenance Infos

Directional local field potentials: A tool to optimize deep brain stimulation


Tinkhauser, Gerd; Pogosyan, Alek; Debove, Ines; Nowacki, Andreas; Shah, Syed Ahmar; Seidel, Kathleen; Tan, Huiling; Brittain, John-Stuart; Petermann, Katrin; di Biase, Lazzaro; Oertel, Markus F; Pollo, Claudio; Brown, Peter; Schuepbach, Michael (2018). Directional local field potentials: A tool to optimize deep brain stimulation. Movement Disorders, 33(1):159-164.

Abstract

Background: Although recently introduced directional DBS leads provide control of the stimulation field, pro- graming is time-consuming. Objectives: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD. Methods: Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months. Results: Normalized beta activity was positively corre- lated with the contact’s clinical efficacy. The two con- tacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. V C 2017 The Authors. Movement Disor- ders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. Key Words: Parkinson’s disease; deep brain stimula- tion; directional leads; local field potentials; DBS programming

Abstract

Background: Although recently introduced directional DBS leads provide control of the stimulation field, pro- graming is time-consuming. Objectives: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD. Methods: Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months. Results: Normalized beta activity was positively corre- lated with the contact’s clinical efficacy. The two con- tacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases. Conclusion: Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. V C 2017 The Authors. Movement Disor- ders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. Key Words: Parkinson’s disease; deep brain stimula- tion; directional leads; local field potentials; DBS programming

Statistics

Citations

Dimensions.ai Metrics
3 citations in Web of Science®
3 citations in Scopus®
3 citations in Microsoft Academic
Google Scholar™

Altmetrics

Downloads

17 downloads since deposited on 15 Feb 2018
17 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:DBS programming, Parkinson's disease, deep brain stimulation, directional leads, local field potentials
Language:English
Date:18 November 2018
Deposited On:15 Feb 2018 14:58
Last Modified:20 Feb 2018 09:08
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0885-3185
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1002/mds.27215

Download

Download PDF  'Directional local field potentials: A tool to optimize deep brain stimulation'.
Preview
Content: Published Version
Filetype: PDF
Size: 584kB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)
Content: Accepted Version
Filetype: PDF - Registered users only until 1 February 2019
Size: 584kB
Embargo till: 2019-02-01