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Hypo- and normothermic perfusion of the liver: Which way to go?


Selten, Jasmijn; Schlegel, Andrea; de Jonge, Jeroen; Dutkowski, Philipp (2017). Hypo- and normothermic perfusion of the liver: Which way to go? Best Practice & Research. Clinical Gastroenterology, 31(2):171-179.

Abstract

The demand of donor livers for transplantation exceeds the supply. In an attempt to maximize the number of potentially usable donor livers, several centers are exploring the role of machine perfusion. This review provides an update on machine perfusion strategies and basic concepts, based on current clinical issues, and discuss challenges, including currently used biomarkers for assessing the quality and viability of perfused organs. The potential benefits of machine perfusion on immunogenicity and the consequences on post-operative immunosuppression management are discussed.

Abstract

The demand of donor livers for transplantation exceeds the supply. In an attempt to maximize the number of potentially usable donor livers, several centers are exploring the role of machine perfusion. This review provides an update on machine perfusion strategies and basic concepts, based on current clinical issues, and discuss challenges, including currently used biomarkers for assessing the quality and viability of perfused organs. The potential benefits of machine perfusion on immunogenicity and the consequences on post-operative immunosuppression management are discussed.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Gastroenterology
Language:English
Date:2017
Deposited On:09 Feb 2018 18:10
Last Modified:25 Nov 2023 08:10
Publisher:Elsevier
ISSN:1521-6918
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.bpg.2017.04.001
PubMed ID:28624105
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