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Modern management of phagocyte defects


Lanini, Lorenza Lisa Serena; Prader, Seraina; Siler, Ulrich; Reichenbach, Janine (2017). Modern management of phagocyte defects. Pediatric Allergy and Immunology, 28(2):124-134.

Abstract

Phagocytic neutrophil granulocytes are among the first immune cells active at sites of infection, forming an important first-line defense against invading microorganisms. Congenital immune defects concerning these phagocytes may be due to reduced neutrophil numbers or function. Management of affected patients depends on the type and severity of disease. Here, we provide an overview of causes and treatment of diseases associated with congenital neutropenia, as well as defects of the phagocytic respiratory burst.

Abstract

Phagocytic neutrophil granulocytes are among the first immune cells active at sites of infection, forming an important first-line defense against invading microorganisms. Congenital immune defects concerning these phagocytes may be due to reduced neutrophil numbers or function. Management of affected patients depends on the type and severity of disease. Here, we provide an overview of causes and treatment of diseases associated with congenital neutropenia, as well as defects of the phagocytic respiratory burst.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:March 2017
Deposited On:16 Feb 2018 19:56
Last Modified:19 Feb 2018 11:09
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0905-6157
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/pai.12654
PubMed ID:27612320

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