Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Palomares, Oscar; Akdis, Mübeccel; Martín-Fontecha, Mar; Akdis, Cezmi A (2017). Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells. Immunological Reviews, 278(1):219-236.

Abstract

Allergy is a major public health problem with a high socio-economic impact. The number of allergic patients is expected to reach to four billion within two decades when the World's population reaches to 10 billion. Our knowledge on the molecular mechanisms underlying allergic diseases and allergen tolerance induction had significant advances during the last years. Nowadays, it is well accepted that the generation and maintenance of allergen-specific regulatory T cells (Tregs) and regulatory B cells (Bregs) and the involvement of their suppressive cytokines and surface molecules are essential for the induction of allergen tolerance. These mechanisms play essential roles for the restoration of healthy immune responses to allergens in allergen-specific immunotherapy (AIT) and healthy immune response during high-dose antigen exposure in beekeepers and cat owners. AIT remains as the only disease-modifying and curative treatment for allergic diseases and represents a perfect model to investigate the antigen-specific immune responses in humans. A large number of clinical trials demonstrated AIT as an effective treatment in many patients, but it still faces several drawbacks in relation to efficacy, safety, long duration, and patient adherence. Novel strategies to overcome these inconveniences, such as the development of novel adjuvants and alternative routes of administration are being developed. The better understanding of the molecular mechanism governing the generation of Treg and Breg cells during allergen tolerance might well open new avenues for alternative therapeutic interventions in allergic diseases and help better understanding of other immune-tolerance-related diseases.

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Immunology and Allergy
Life Sciences > Immunology
Language:English
Date:July 2017
Deposited On:23 Feb 2018 19:24
Last Modified:18 Jan 2025 02:37
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0105-2896
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/imr.12555
PubMed ID:28658547
Project Information:
  • Funder: FP7
  • Grant ID: 260895
  • Project Title: PREDICTA - Post-infectious immune reprogramming and its association with persistence and chronicity of respiratory allergic diseases
  • Funder: FP7
  • Grant ID: 261357
  • Project Title: MEDALL - Mechanisms of the Development of ALLergy
Full text not available from this repository.

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
231 citations in Web of Science®
254 citations in Scopus®
Google Scholar™

Altmetrics

Authors, Affiliations, Collaborations

Similar Publications