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El rol de la electroporación irreversible en la cirugía hepato-bilio-pancreática


Sánchez-Velázquez, Patricia; Clavien, Pierre-Alain (2017). El rol de la electroporación irreversible en la cirugía hepato-bilio-pancreática. Cirugía Española, 95(6):307-312.

Abstract

Irreversible electroporation is a novel technique growing in popularity over the last years among the ablative modalities. Its unique action mechanism produces irreversible nanopores in the membrane of the cell leading to apoptosis; therefore irreversible electroporation can be used to ablate substantial volumes of tissue without the undesirable thermal effects as the "heat sink effect". Moreover the extracellular matrix is left unperturbed, thus sparing the structural architecture of surrounding structures such as bile ducts and blood vessels. In the last years its use has been widespread in both liver and pancreatic ablation. Irreversible electroporation has shown its safety with however some caution, feasibility and favorable outcomes in clinical settings such as unresectable locally advanced disease in which the surgical and therapeutic options are very limited.

Abstract

Irreversible electroporation is a novel technique growing in popularity over the last years among the ablative modalities. Its unique action mechanism produces irreversible nanopores in the membrane of the cell leading to apoptosis; therefore irreversible electroporation can be used to ablate substantial volumes of tissue without the undesirable thermal effects as the "heat sink effect". Moreover the extracellular matrix is left unperturbed, thus sparing the structural architecture of surrounding structures such as bile ducts and blood vessels. In the last years its use has been widespread in both liver and pancreatic ablation. Irreversible electroporation has shown its safety with however some caution, feasibility and favorable outcomes in clinical settings such as unresectable locally advanced disease in which the surgical and therapeutic options are very limited.

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Other titles:The role of the irreversible electroporation in the hepato-pancreatico-biliary surgery
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
Dewey Decimal Classification:610 Medicine & health
Language:Spanish
Date:2017
Deposited On:09 Feb 2018 18:03
Last Modified:19 Feb 2018 11:11
Publisher:Elsevier
ISSN:0009-739X
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.ciresp.2017.01.007
PubMed ID:28318494

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