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Contact heat evoked potentials: Reliable acquisition from lower extremities


Rosner, J; Hubli, M; Hostettler, P; Scheuren, P S; Rinert, J; Kramer, J L K; Hupp, M; Curt, A; Jutzeler, C R (2018). Contact heat evoked potentials: Reliable acquisition from lower extremities. Clinical Neurophysiology, 129(3):584-591.

Abstract

OBJECTIVE: To investigate test-retest reliability of contact heat evoked potentials (CHEPs) from lower extremities using two different stimulation protocols, i.e., normal and increased baseline temperature.
METHODS: A total of 32 able-bodied subjects were included and a subset (N = 22) was retested. CHEPs were recorded from three different dermatomes of the lower extremity (i.e., L2, L5, and S2). Test-retest reliability of CHEPs acquisition after simulation in various lower limb dermatomes using different stimulation protocols was analyzed.
RESULTS: The study revealed an improved acquisition of CHEPS employing the increased baseline protocol, particularly when stimulating more distal sites, i.e., dermatome L5 and S2. Based on repeatability coefficients, CHEP latency (N2 potential) emerged as the most robust CHEP parameter. Although CHEP amplitudes (N2P2 complex) and pain ratings were decreased in the retest, amplitudes still showed fair to excellent intraclass correlation coefficients using normal baseline or increased baseline temperature, respectively.
CONCLUSIONS: This is the first study to demonstrate that CHEPs acquisition from the lower extremities is improved by increasing the baseline temperature of the thermode.
SIGNIFICANCE: This study highlights the usability of CHEPs as a viable diagnostic method to study small fiber integrity.

Abstract

OBJECTIVE: To investigate test-retest reliability of contact heat evoked potentials (CHEPs) from lower extremities using two different stimulation protocols, i.e., normal and increased baseline temperature.
METHODS: A total of 32 able-bodied subjects were included and a subset (N = 22) was retested. CHEPs were recorded from three different dermatomes of the lower extremity (i.e., L2, L5, and S2). Test-retest reliability of CHEPs acquisition after simulation in various lower limb dermatomes using different stimulation protocols was analyzed.
RESULTS: The study revealed an improved acquisition of CHEPS employing the increased baseline protocol, particularly when stimulating more distal sites, i.e., dermatome L5 and S2. Based on repeatability coefficients, CHEP latency (N2 potential) emerged as the most robust CHEP parameter. Although CHEP amplitudes (N2P2 complex) and pain ratings were decreased in the retest, amplitudes still showed fair to excellent intraclass correlation coefficients using normal baseline or increased baseline temperature, respectively.
CONCLUSIONS: This is the first study to demonstrate that CHEPs acquisition from the lower extremities is improved by increasing the baseline temperature of the thermode.
SIGNIFICANCE: This study highlights the usability of CHEPs as a viable diagnostic method to study small fiber integrity.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:March 2018
Deposited On:08 Mar 2018 19:39
Last Modified:19 Aug 2018 14:30
Publisher:Elsevier
ISSN:1388-2457
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.clinph.2017.12.034
PubMed ID:29414402
Project Information:
  • : FunderSNSF
  • : Grant ID320030_169250
  • : Project TitleImpact of deafferentation on descending pain control systems
  • : FunderFP7
  • : Grant ID319970
  • : Project TitleDIVERCITIES - Governing Urban Diversity: Creating Social Cohesion, Social Mobility and Economic Performance in Today's Hyper-diversified Cities

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