Peña, Cohue; Hurt, Ed; Panse, Vikram Govind (2017). Eukaryotic ribosome assembly, transport and quality control. Nature Structural & Molecular Biology, 24(9):689-699.
Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved assembly factors. Here, we discuss mechanisms by which the ribosome assembly and nucleocytoplasmic transport machineries collaborate to produce functional ribosomes. We also highlight recent cryo-EM studies that provided unprecedented snapshots of ribosomes during assembly and quality control.
Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved assembly factors. Here, we discuss mechanisms by which the ribosome assembly and nucleocytoplasmic transport machineries collaborate to produce functional ribosomes. We also highlight recent cryo-EM studies that provided unprecedented snapshots of ribosomes during assembly and quality control.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Institute of Medical Microbiology |
| Dewey Decimal Classification: | 570 Life sciences; biology
610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Structural Biology
Life Sciences > Molecular Biology |
| Language: | English |
| Date: | 7 September 2017 |
| Deposited On: | 27 Feb 2018 17:05 |
| Last Modified: | 26 Nov 2023 08:01 |
| Publisher: | Nature Publishing Group |
| ISSN: | 1545-9985 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1038/nsmb.3454 |
| PubMed ID: | 28880863 |
Peña, Cohue