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Legionella quorum sensing and its role in pathogen-host interactions


Personnic, Nicolas; Striednig, Bianca; Hilbi, Hubert (2018). Legionella quorum sensing and its role in pathogen-host interactions. Current Opinion in Microbiology, 41:29-35.

Abstract

Legionella pneumophila is a water-borne opportunistic pathogen causing a life-threatening pneumonia called 'Legionnaires' disease'. The Legionella quorum sensing (Lqs) system produces and responds to the α-hydroxyketone signaling molecule 3-hydroxypentadecane-4-one (Legionella autoinducer-1, LAI-1). The Lqs system controls the switch between the replicative/non-virulent and the transmissive/virulent phase of L. pneumophila, and it is a major regulator of natural competence, motility and virulence of the pathogen. Yet, beyond gene regulation, LAI-1 also directly affects pathogen-host interactions, since the signaling molecule modulates the migration of eukaryotic cells. Genes encoding Lqs homologues are present in many environmental bacteria, suggesting that α-hydroxyketone signaling is widely used for inter-bacterial as well as inter-kingdom signaling. In this review we summarize recent advances on the characterization of the Lqs system and its role in L. pneumophila-host cell interactions.

Abstract

Legionella pneumophila is a water-borne opportunistic pathogen causing a life-threatening pneumonia called 'Legionnaires' disease'. The Legionella quorum sensing (Lqs) system produces and responds to the α-hydroxyketone signaling molecule 3-hydroxypentadecane-4-one (Legionella autoinducer-1, LAI-1). The Lqs system controls the switch between the replicative/non-virulent and the transmissive/virulent phase of L. pneumophila, and it is a major regulator of natural competence, motility and virulence of the pathogen. Yet, beyond gene regulation, LAI-1 also directly affects pathogen-host interactions, since the signaling molecule modulates the migration of eukaryotic cells. Genes encoding Lqs homologues are present in many environmental bacteria, suggesting that α-hydroxyketone signaling is widely used for inter-bacterial as well as inter-kingdom signaling. In this review we summarize recent advances on the characterization of the Lqs system and its role in L. pneumophila-host cell interactions.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:27 November 2018
Deposited On:27 Feb 2018 17:12
Last Modified:19 Aug 2018 14:40
Publisher:Elsevier
ISSN:1369-5274
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.mib.2017.11.010
PubMed ID:29190490
Project Information:
  • : FunderSNSF
  • : Grant ID31003A_153200
  • : Project TitleFormation of the Legionella-containing vacuole: Effectors targeting retrograde trafficking and microtubules
  • : FunderSNSF
  • : Grant IDPZ00P3_161492
  • : Project TitleHétérogénéité phénotypique de Legionella pneumophila lors d'infection de cellules phagocytaires

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