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Synergy of cefotaxime and fosfomycin against penicillin-resistant pneumococci


Barakett, V; Lesage, D; Delisle, F; Burghoffer, B; Richard, G; Vergez, P; Petit, J C (1993). Synergy of cefotaxime and fosfomycin against penicillin-resistant pneumococci. Journal of Antimicrobial Chemotherapy, 31(1):105-9.

Abstract

The killing kinetics of cefotaxime and fosfomycin, alone and in combination, against seven clinical isolates of penicillin-resistant pneumococci were studied. The antibiotics were tested at 1 x, 2 x and 4 x the MIC for each individual isolate. The results showed a synergic interaction of the two antibiotics for three of the seven strains. This strategy may be useful clinically.

Abstract

The killing kinetics of cefotaxime and fosfomycin, alone and in combination, against seven clinical isolates of penicillin-resistant pneumococci were studied. The antibiotics were tested at 1 x, 2 x and 4 x the MIC for each individual isolate. The results showed a synergic interaction of the two antibiotics for three of the seven strains. This strategy may be useful clinically.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:January 1993
Deposited On:28 Feb 2018 14:53
Last Modified:13 Apr 2018 11:37
Publisher:Oxford University Press
ISSN:0305-7453
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/jac/31.1.105
PubMed ID:8444654

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