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Synthesis of Highly Substituted 3-Pyrrolin-2-ones from N,N-Disubstituted α-Amino Acids

Samper Barceló, Víctor; Bienz, Stefan (2018). Synthesis of Highly Substituted 3-Pyrrolin-2-ones from N,N-Disubstituted α-Amino Acids. Journal of Organic Chemistry, 83(5):2734-2743.

Abstract

Highly functionalized 5-membered N-heterocyclic compounds, 4-aryl-3-chloro-5-methoxy-1-methyl-3-pyrrolin-2- ones, have been synthesized in moderate to high yields by the reaction of N,N-dimethylated aromatic α-amino acids with oxalyl chloride, followed by solvolysis with MeOH. The products possess a number of functional groups such as an amide, a mixed amido/alkoxy acetal, a vinyl halide, and an alkene and thus are promising candidates to be used as starting materials for the synthesis of diverse five-membered N-heterocyclic compounds.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > Organic Chemistry
Language:English
Date:2018
Deposited On:16 Mar 2018 13:54
Last Modified:18 Jan 2025 02:39
Publisher:American Chemical Society (ACS)
ISSN:0022-3263
OA Status:Closed
Publisher DOI:https://doi.org/10.1021/acs.joc.7b03187

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