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Intrathecal antibody responses to GalC in Guillain-Barré syndrome triggered by Mycoplasma pneumoniae


Meyer Sauteur, Patrick M; Huizinga, Ruth; Tio-Gillen, Anne P; Drenthen, Judith; Unger, Wendy W J; Jacobs, Enno; van Rossum, Annemarie M C; Jacobs, Bart C (2018). Intrathecal antibody responses to GalC in Guillain-Barré syndrome triggered by Mycoplasma pneumoniae. Journal of Neuroimmunology, 314:13-16.

Abstract

Mycoplasma pneumoniae (Mp) triggers Guillain-Barré syndrome (GBS) and elicits anti-galactocerebroside (GalC) antibodies. Specifically anti-GalC IgG is associated with Mp-GBS, possibly because of its better ability to cross the blood-nerve barrier (BNB). We here investigated CSF for the presence of anti-GalC in GBS. Intrathecal anti-GalC was found in 46% of Mp-GBS patients (n=6/13), in contrast to 16% of GBS controls (n=4/25) and 0% of non-GBS controls (n=0/7). The antibodies most likely originated from increased BNB permeability and/or intrathecal synthesis. Intrathecal anti-GalC IgG was specifically associated with Mp-GBS, further supporting that anti-GalC IgG contributes to the pathogenesis of GBS.

Abstract

Mycoplasma pneumoniae (Mp) triggers Guillain-Barré syndrome (GBS) and elicits anti-galactocerebroside (GalC) antibodies. Specifically anti-GalC IgG is associated with Mp-GBS, possibly because of its better ability to cross the blood-nerve barrier (BNB). We here investigated CSF for the presence of anti-GalC in GBS. Intrathecal anti-GalC was found in 46% of Mp-GBS patients (n=6/13), in contrast to 16% of GBS controls (n=4/25) and 0% of non-GBS controls (n=0/7). The antibodies most likely originated from increased BNB permeability and/or intrathecal synthesis. Intrathecal anti-GalC IgG was specifically associated with Mp-GBS, further supporting that anti-GalC IgG contributes to the pathogenesis of GBS.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Immunology, Immunology and Allergy, Neurology, Clinical Neurology
Language:English
Date:15 January 2018
Deposited On:02 May 2018 10:09
Last Modified:24 Sep 2019 23:24
Publisher:Elsevier
ISSN:0165-5728
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.jneuroim.2017.11.011
PubMed ID:29301655
Project Information:
  • : FunderSNSF
  • : Grant IDPBZHP3_147290
  • : Project TitleAntigenic variation of Mycoplasma pneumoniae: the key to immune evasion and bacterial persistence?

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