Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Migration von ZORA auf die Software DSpace

ZORA will change to a new software on 8th September 2025. Please note: deadline for new submissions is 21th July 2025!

Information & dates for training courses can be found here: Information on Software Migration.

Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism

Aristizabal Prada, Elke Tatjana; Castellano, Isabella; Sušnik, Eva; Yang, Yuhong; Meyer, Lucie S; Tetti, Martina; Beuschlein, Felix; Reincke, Martin; Williams, Tracy A (2018). Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism. International Journal of Molecular Sciences, 19(4):1124.

Abstract

Primary aldosteronism is the most common form of endocrine hypertension with a prevalence of 6% in the general population with hypertension. The genetic basis of the four familial forms of primary aldosteronism (familial hyperaldosteronism FH types I-IV) and the majority of sporadic unilateral aldosterone-producing adenomas has now been resolved. Familial forms of hyperaldosteronism are, however, rare. The sporadic forms of the disease prevail and these are usually caused by either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. Aldosterone-producing adenomas frequently carry a causative somatic mutation in either of a number of genes with the gene, encoding an inwardly rectifying potassium channel, a recurrent target harboring mutations at a prevalence of more than 40% worldwide. Other than genetic variations, gene expression profiling of aldosterone-producing adenomas has shed light on the genes and intracellular signalling pathways that may play a role in the pathogenesis and pathophysiology of these tumors.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Physical Sciences > Catalysis
Life Sciences > Molecular Biology
Physical Sciences > Spectroscopy
Physical Sciences > Computer Science Applications
Physical Sciences > Physical and Theoretical Chemistry
Physical Sciences > Organic Chemistry
Physical Sciences > Inorganic Chemistry
Language:English
Date:9 April 2018
Deposited On:29 May 2018 14:00
Last Modified:18 Jul 2025 01:36
Publisher:MDPI Publishing
ISSN:1422-0067
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3390/ijms19041124
PubMed ID:29642543
Download PDF  'Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism'.
Preview
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
13 citations in Web of Science®
13 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

61 downloads since deposited on 29 May 2018
7 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications