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Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model


Keller, Nadia; Andreoni, Federica; Reiber, Claudine; Luethi-Schaller, Helga; Schuepbach, Reto Andreas; Moch, Holger; Maggio, Ewerton Marques; Zinkernagel, Annelies Sophie (2018). Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model. American Journal of Pathology, 188(7):1517-1523.

Abstract

Streptococcal necrotizing fasciitis (NF) causes high morbidity and mortality despite state-of-the-art therapy. Low incidence and rapid disease progression, necessitating immediate initiation of therapy, have proven challenging aspects for setting up prospective randomized trials. This has resulted in little therapeutic progress over the past decade. The validation of reliable murine NF models to study both pathogenesis and optimized therapeutic regimens of streptococcal NF are thus essential. In this study, we characterized a murine NF model and compared the pathology with an in-depth tissue analysis of streptococcal NF in patients. We found that the streptococcal murine NF model closely reflected all histologic characteristics encountered in human streptococcal NF. This murine NF model helps understanding of human NF pathology better in a time-dependent manner and will allow studying novel therapeutic options in the future.

Abstract

Streptococcal necrotizing fasciitis (NF) causes high morbidity and mortality despite state-of-the-art therapy. Low incidence and rapid disease progression, necessitating immediate initiation of therapy, have proven challenging aspects for setting up prospective randomized trials. This has resulted in little therapeutic progress over the past decade. The validation of reliable murine NF models to study both pathogenesis and optimized therapeutic regimens of streptococcal NF are thus essential. In this study, we characterized a murine NF model and compared the pathology with an in-depth tissue analysis of streptococcal NF in patients. We found that the streptococcal murine NF model closely reflected all histologic characteristics encountered in human streptococcal NF. This murine NF model helps understanding of human NF pathology better in a time-dependent manner and will allow studying novel therapeutic options in the future.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Pathology and Forensic Medicine
Language:English
Date:22 April 2018
Deposited On:06 Jun 2018 14:30
Last Modified:24 Sep 2019 23:30
Publisher:Elsevier
ISSN:0002-9440
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.ajpath.2018.03.009
PubMed ID:29684366
Project Information:
  • : FunderSNSF
  • : Grant IDPZ00P3_136639
  • : Project TitleCytoprotection through non Anticoagulant Engineered Chimeric Activated Protein C

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