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No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients


Strouvelle, Victoria P; Braun, Dominique L; Vongrad, Valentina; Scherrer, Alexandra U; Kok, Yik Lim; Kouyos, Roger D; Stöckle, Marcel; Rauch, Andri; Darling, Katharine; Hoffmann, Matthias; Metzner, Karin J; Günthard, Huldrych F; Zurich Primary HIV Infection Study; Swiss HIV Cohort Study (2018). No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients. Journal of Infectious Diseases, 217(12):1883-1888.

Abstract

Pegylated interferon-alpha (pIFN-α) is suggested to lower human immunodeficiency virus type-1 (HIV-1) DNA load in antiretroviral therapy (ART)-treated patients. We studied kinetics of HIV-1 DNA levels in 40 HIV-1/hepatitis C virus (HCV) coinfected patients, treated with pIFN-α for HCV and categorized into 3 groups according to start of ART: chronic HIV-1 infection (n = 22), acute HIV-1 infection (n = 8), no-ART (n = 10). Total HIV-1 DNA levels in 247 peripheral blood mononuclear cell samples were stable before, during, and after pIFN-α treatment in all groups. Our results question the benefit of pIFN-α as an immunotherapeutic agent for reducing the HIV-1 reservoir.

Abstract

Pegylated interferon-alpha (pIFN-α) is suggested to lower human immunodeficiency virus type-1 (HIV-1) DNA load in antiretroviral therapy (ART)-treated patients. We studied kinetics of HIV-1 DNA levels in 40 HIV-1/hepatitis C virus (HCV) coinfected patients, treated with pIFN-α for HCV and categorized into 3 groups according to start of ART: chronic HIV-1 infection (n = 22), acute HIV-1 infection (n = 8), no-ART (n = 10). Total HIV-1 DNA levels in 247 peripheral blood mononuclear cell samples were stable before, during, and after pIFN-α treatment in all groups. Our results question the benefit of pIFN-α as an immunotherapeutic agent for reducing the HIV-1 reservoir.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:25 May 2018
Deposited On:06 Jun 2018 16:06
Last Modified:17 Sep 2019 19:21
Publisher:Oxford University Press
ISSN:0022-1899
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/infdis/jiy131
PubMed ID:29528417
Project Information:
  • : FunderSNSF
  • : Grant ID33CS30_148522
  • : Project TitleSwiss HIV Cohort Study (SHCS)
  • : FunderSNSF
  • : Grant ID33CS30_177499
  • : Project TitleSwiss HIV Cohort Study (SHCS)

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