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Electrocochleographic responses before and after short-term suprathreshold electrical stimulation in human cochlear implant recipients


Hoesli, Marco; Huber, Alexander; Pfiffner, Flurin; Veraguth, Dorothe; Röösli, Christof; Dalbert, Adrian (2018). Electrocochleographic responses before and after short-term suprathreshold electrical stimulation in human cochlear implant recipients. Otology & Neurotology, 39(8):e635-e641.

Abstract

OBJECTIVE: To assess changes in electrocochleographic (ECoG) responses following short-term suprathreshold electrical stimulation during cochlear implant (CI) telemetry in CI recipients.
METHODS: Extracochlear ECoG recordings were conducted before and after intraoperative short-term suprathreshold electrical stimulation. Tone bursts at 500, 750, and 1000 Hz as well as clicks were used as acoustic stimuli. Changes of ECoG responses were correlated to calculated maximum electrical charge levels.
RESULTS: Fourteen subjects were included. On average, no significant changes of ECoG responses occurred in the earliest postoperative phase; therefore, also following short-term suprathreshold electrical stimulation. However, one subject (S7) showed a decrease of ECoG responses. Neural as well as hair cell components of the ECoG signal were affected. On average, the maximum electrical charge level was 22 nC (range, 15-37 nC). In S7, the maximum electrical charge level was 17 nC. No correlations were found between maximum electrical charge levels and changes of ECoG signals.
CONCLUSION: In a majority of cases, electrophysiological responses to acoustic stimuli remain unchanged in the earliest postoperative phase. However, deterioration of cochlear function occurs in this phase. Neural as well as hair cell components of the ECoG signal are affected. Such deterioration is not associated with unusually high electrical charge levels during CI telemetry. Overall, our results support the notion that an electrical charge applied at levels used in the clinical routine does not have an acute deleterious effect on cochlear function.

Abstract

OBJECTIVE: To assess changes in electrocochleographic (ECoG) responses following short-term suprathreshold electrical stimulation during cochlear implant (CI) telemetry in CI recipients.
METHODS: Extracochlear ECoG recordings were conducted before and after intraoperative short-term suprathreshold electrical stimulation. Tone bursts at 500, 750, and 1000 Hz as well as clicks were used as acoustic stimuli. Changes of ECoG responses were correlated to calculated maximum electrical charge levels.
RESULTS: Fourteen subjects were included. On average, no significant changes of ECoG responses occurred in the earliest postoperative phase; therefore, also following short-term suprathreshold electrical stimulation. However, one subject (S7) showed a decrease of ECoG responses. Neural as well as hair cell components of the ECoG signal were affected. On average, the maximum electrical charge level was 22 nC (range, 15-37 nC). In S7, the maximum electrical charge level was 17 nC. No correlations were found between maximum electrical charge levels and changes of ECoG signals.
CONCLUSION: In a majority of cases, electrophysiological responses to acoustic stimuli remain unchanged in the earliest postoperative phase. However, deterioration of cochlear function occurs in this phase. Neural as well as hair cell components of the ECoG signal are affected. Such deterioration is not associated with unusually high electrical charge levels during CI telemetry. Overall, our results support the notion that an electrical charge applied at levels used in the clinical routine does not have an acute deleterious effect on cochlear function.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Otorhinolaryngology
Life Sciences > Sensory Systems
Health Sciences > Neurology (clinical)
Uncontrolled Keywords:Sensory Systems, Otorhinolaryngology, Clinical Neurology
Language:English
Date:9 July 2018
Deposited On:06 Aug 2018 14:29
Last Modified:29 Jul 2020 07:27
Publisher:Lippincott Williams & Wilkins
ISSN:1531-7129
OA Status:Green
Publisher DOI:https://doi.org/10.1097/MAO.0000000000001889
PubMed ID:29985805

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