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Value of F-FET PET in adult brainstem glioma


Abstract

PURPOSE
To investigate F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG).
MATERIALS AND METHODS
FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUV, TBR, and time activity curves of FET-PET were calculated.
RESULTS
Progressive gliomas had higher SUV (3.57 ± 1.47 vs. 1.60 ± 0.51; p = 0.003) and TBR (3.00 ± 1.12 vs. 1.36 ± 0.33; p = 0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBR < 2.0 compared to tumors with TBR > 2.0 (665 ± 32 days versus 220 ± 39 days; p < 0.001).
CONCLUSION
FET-PET uptake might be associated with disease progression in adult BSG.

Abstract

PURPOSE
To investigate F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG).
MATERIALS AND METHODS
FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUV, TBR, and time activity curves of FET-PET were calculated.
RESULTS
Progressive gliomas had higher SUV (3.57 ± 1.47 vs. 1.60 ± 0.51; p = 0.003) and TBR (3.00 ± 1.12 vs. 1.36 ± 0.33; p = 0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBR < 2.0 compared to tumors with TBR > 2.0 (665 ± 32 days versus 220 ± 39 days; p < 0.001).
CONCLUSION
FET-PET uptake might be associated with disease progression in adult BSG.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neuroradiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:8 February 2018
Deposited On:07 Aug 2018 10:17
Last Modified:07 Aug 2018 10:49
Publisher:Elsevier
ISSN:0899-7071
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.clinimag.2018.01.015
PubMed ID:29448122

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