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The role of FDG PET/CT in therapy control of aortic graft infection


Husmann, Lars; Ledergerber, Bruno; Anagnostopoulos, Alexia; Stolzmann, Paul; Sah, Bert-Ram; Burger, Irene A; Pop, Roxana; Weber, Alberto; Mayer, Dieter; Rancic, Zoran; Hasse, Barbara; VASGRA Cohort Study (2018). The role of FDG PET/CT in therapy control of aortic graft infection. European Journal of Nuclear Medicine and Molecular Imaging, 45(11):1987-1997.

Abstract

PURPOSE: F-FDG PET/CT (PET/CT) is a useful tool for the diagnosis of aortic graft infection (AGI), but has rarely been used to influence therapeutic decisions during follow-up. We aimed to study the role of PET/CT in the long-term monitoring of patients.
METHODS: Participants of the prospective Vascular Graft Infection Cohort Study (VASGRA) were included if they had microbiologically proven AGI. We quantified the metabolic activity in PET/CT by using maximum standardized uptake value (SUV) and further classified it as being focal or diffuse. Multivariable linear regression models were fit using generalized estimating equations to investigate factors associated with SUV over time.
RESULTS: Sixty-eight participants with AGI contributed to 266 PET/CTs including 36 examinations performed after stop of antimicrobial therapy. Higher C-reactive protein (CRP) (adjusted coefficient per log mg/L 0.05 [95% C.I. 0.02-0.08]) was associated with higher SUV. CRP, metabolic and clinical findings informed the decision to either start (medians of SUV 7.1 and CRP 31.5 mg/L; 100% focal uptake), escalate (SUV 9.5; CRP 31.5; 100% focal uptake), continue (SUV 6.0; CRP 9.95 mg/L; 90% focal uptake), or stop (SUV 4.3; CRP 3.5 mg/L; 61% focal uptake) antibiotic treatment. Of note, decisions to escalate or continue antibiotic treatment were taken despite normal CRP values in 12.5 and 35.7% of PET/CTs, respectively.
CONCLUSIONS: Consecutive PET/CTs could influence the clinical decision-making in patients with AGI in the near future. More studies on the use of PET/CT in case of aortic graft infection may offer the potential for individualized treatment approaches. CLINICALTRIALS.
GOV IDENTIFIER: NCT01821664.

Abstract

PURPOSE: F-FDG PET/CT (PET/CT) is a useful tool for the diagnosis of aortic graft infection (AGI), but has rarely been used to influence therapeutic decisions during follow-up. We aimed to study the role of PET/CT in the long-term monitoring of patients.
METHODS: Participants of the prospective Vascular Graft Infection Cohort Study (VASGRA) were included if they had microbiologically proven AGI. We quantified the metabolic activity in PET/CT by using maximum standardized uptake value (SUV) and further classified it as being focal or diffuse. Multivariable linear regression models were fit using generalized estimating equations to investigate factors associated with SUV over time.
RESULTS: Sixty-eight participants with AGI contributed to 266 PET/CTs including 36 examinations performed after stop of antimicrobial therapy. Higher C-reactive protein (CRP) (adjusted coefficient per log mg/L 0.05 [95% C.I. 0.02-0.08]) was associated with higher SUV. CRP, metabolic and clinical findings informed the decision to either start (medians of SUV 7.1 and CRP 31.5 mg/L; 100% focal uptake), escalate (SUV 9.5; CRP 31.5; 100% focal uptake), continue (SUV 6.0; CRP 9.95 mg/L; 90% focal uptake), or stop (SUV 4.3; CRP 3.5 mg/L; 61% focal uptake) antibiotic treatment. Of note, decisions to escalate or continue antibiotic treatment were taken despite normal CRP values in 12.5 and 35.7% of PET/CTs, respectively.
CONCLUSIONS: Consecutive PET/CTs could influence the clinical decision-making in patients with AGI in the near future. More studies on the use of PET/CT in case of aortic graft infection may offer the potential for individualized treatment approaches. CLINICALTRIALS.
GOV IDENTIFIER: NCT01821664.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiovascular Surgery
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Aortic vascular graft infection; PET/CT; SUVmax, monitoring; Treatment response
Language:English
Date:11 June 2018
Deposited On:22 Aug 2018 13:40
Last Modified:23 Sep 2018 06:16
Publisher:Springer
ISSN:1619-7070
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s00259-018-4069-1
PubMed ID:29948106

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