Header

UZH-Logo

Maintenance Infos

Heterogeneity in Malignant Pleural Mesothelioma


Oehl, Kathrin; Vrugt, Bart; Opitz, Isabelle; Meerang, Mayura (2018). Heterogeneity in Malignant Pleural Mesothelioma. International Journal of Molecular Sciences, 19(6):E1603.

Abstract

Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i) between patients; (ii) within different areas of a given tumor in terms of different clonal compositions; and (iii) during treatment over time. The aim of the present review is to highlight this diversity and its therapeutic implications.

Abstract

Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i) between patients; (ii) within different areas of a given tumor in terms of different clonal compositions; and (iii) during treatment over time. The aim of the present review is to highlight this diversity and its therapeutic implications.

Statistics

Citations

Dimensions.ai Metrics
4 citations in Web of Science®
3 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

12 downloads since deposited on 05 Sep 2018
12 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Thoracic Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:30 May 2018
Deposited On:05 Sep 2018 13:59
Last Modified:26 Feb 2019 08:10
Publisher:MDPI Publishing
ISSN:1422-0067
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3390/ijms19061603
PubMed ID:29848954

Download

Download PDF  'Heterogeneity in Malignant Pleural Mesothelioma'.
Preview
Content: Published Version
Filetype: PDF
Size: 655kB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)