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Tissue oximetry by diffusive reflective visible light spectroscopy: Comparison of algorithms and their robustness


Nasseri, Nassim; Kleiser, Stefan; Wolf, Ursula; Wolf, Martin (2018). Tissue oximetry by diffusive reflective visible light spectroscopy: Comparison of algorithms and their robustness. Journal of Biophotonics:e201700367.

Abstract

It is essential to measure tissue oxygen saturation (StO2) locally and in thin layers of tissue, for example, the bronchial mucosa, skin flaps and small bones. Visible light spectroscopy (VLS) with a shallow penetration depth is suitable method. Although several VLS algorithms have been developed and described, they have not yet been compared to each other. This hinders attempts to compare the clinical results obtained by different algorithms. To address this issue, we compared the algorithms of Harrison, Knoefel, Pittman‐Duling, Sato and our OxyVLS oximeter, which applies the algorithm from Wodick and Lübbers, in a liquid phantom with optical properties of human tissue. We generally observed considerable differences between the algorithms, which were StO2 dependent. Exceptions were OxyVLS and Sato, showing a high level of agreement with negligible StO2 dependency. In spite of the considerable deviation between the other algorithms, the difference of StO2 between them in clinically normal StO2 was <10%. We did not observe any dependency of the algorithms on hemoglobin content of the phantom or temperature.

Abstract

It is essential to measure tissue oxygen saturation (StO2) locally and in thin layers of tissue, for example, the bronchial mucosa, skin flaps and small bones. Visible light spectroscopy (VLS) with a shallow penetration depth is suitable method. Although several VLS algorithms have been developed and described, they have not yet been compared to each other. This hinders attempts to compare the clinical results obtained by different algorithms. To address this issue, we compared the algorithms of Harrison, Knoefel, Pittman‐Duling, Sato and our OxyVLS oximeter, which applies the algorithm from Wodick and Lübbers, in a liquid phantom with optical properties of human tissue. We generally observed considerable differences between the algorithms, which were StO2 dependent. Exceptions were OxyVLS and Sato, showing a high level of agreement with negligible StO2 dependency. In spite of the considerable deviation between the other algorithms, the difference of StO2 between them in clinically normal StO2 was <10%. We did not observe any dependency of the algorithms on hemoglobin content of the phantom or temperature.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2018
Deposited On:07 Sep 2018 09:35
Last Modified:23 Sep 2018 06:16
Publisher:Wiley-VCH Verlag
ISSN:1864-063X
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/jbio.201700367
PubMed ID:29575571

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