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Coercivity Determines Magnetic Particle Heating


Starsich, Fabian H L; Eberhardt, Christian; Boss, Andreas; Hirt, Ann M; Pratsinis, Sotiris E (2018). Coercivity Determines Magnetic Particle Heating. Advanced Healthcare Materials, 7(19):1800287.

Abstract

Diseased cell treatment by heating with magnetic nanoparticles is hindered by their required high concentrations. A clear relationship between heating efficiency and magnetic properties of nanoparticles has not been attained experimentally yet due to limited availability of magnetic nanoparticles with varying size and composition. Here, versatile flame aerosol technology is used for the synthesis of 21 types of ferro-/ferrimagnetic nanocrystals with varying composition, size, and morphology for hyperthermia and thermoablation therapy. Heating efficiency, magnetic hysteresis, and first-order reversal curves of these materials are compared. The maximum heating performance occurs near the transition from superparamagnetic to single domain state, regardless of particle composition. Most importantly, the ratio between saturation magnetization and coercivity can be linked to the heating properties of magnetic nanoparticles. Magnetic interaction is controlled by changes in the architecture of the nanoparticles and closely analyzed by first-order reversal curves. Silica-coated nonstoichiometric Gd-Zn ferrite exhibits the most promising therapeutic capability at relatively low particle concentrations, as shown in vitro with cancerous prostate cells.

Abstract

Diseased cell treatment by heating with magnetic nanoparticles is hindered by their required high concentrations. A clear relationship between heating efficiency and magnetic properties of nanoparticles has not been attained experimentally yet due to limited availability of magnetic nanoparticles with varying size and composition. Here, versatile flame aerosol technology is used for the synthesis of 21 types of ferro-/ferrimagnetic nanocrystals with varying composition, size, and morphology for hyperthermia and thermoablation therapy. Heating efficiency, magnetic hysteresis, and first-order reversal curves of these materials are compared. The maximum heating performance occurs near the transition from superparamagnetic to single domain state, regardless of particle composition. Most importantly, the ratio between saturation magnetization and coercivity can be linked to the heating properties of magnetic nanoparticles. Magnetic interaction is controlled by changes in the architecture of the nanoparticles and closely analyzed by first-order reversal curves. Silica-coated nonstoichiometric Gd-Zn ferrite exhibits the most promising therapeutic capability at relatively low particle concentrations, as shown in vitro with cancerous prostate cells.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Physical Sciences > Biomaterials
Physical Sciences > Biomedical Engineering
Life Sciences > Pharmaceutical Science
Language:English
Date:1 October 2018
Deposited On:11 Sep 2018 14:13
Last Modified:29 Jul 2020 07:40
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:2192-2640
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/adhm.201800287
PubMed ID:30088699

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