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Next generation neuro-oncology


Weller, Michael (2018). Next generation neuro-oncology. European Journal of Cancer, 96:1-5.

Abstract

Neuro-oncology has evolved as a growing, but still small, highly specialised and multidisciplinary field at the interface of several diagnostic and therapeutic disciplines. The major challenge in the field of primary tumours is to translate the almost unique progress in deciphering the highly complex molecular genetic nature of many primary brain tumours, notably glioblastoma, into advances that allow for clinical benefit for affected patients. Furthermore, metastases to the central nervous system are an increasingly prevalent complication in many systemic cancers. Their diagnosis and management require major expertise, notably with consideration of several new systemic therapy options, such as targeted therapy and immuno-oncology approaches. These new treatments contribute to challenges within the third major domain of neuro-oncology, the diagnosis, treatment and prevention of nervous system toxicity of old and new anti-cancer treatments. All these considerations strongly argue for the development of specialised centres of excellence to improve care for patients with brain tumour across Europe.

Abstract

Neuro-oncology has evolved as a growing, but still small, highly specialised and multidisciplinary field at the interface of several diagnostic and therapeutic disciplines. The major challenge in the field of primary tumours is to translate the almost unique progress in deciphering the highly complex molecular genetic nature of many primary brain tumours, notably glioblastoma, into advances that allow for clinical benefit for affected patients. Furthermore, metastases to the central nervous system are an increasingly prevalent complication in many systemic cancers. Their diagnosis and management require major expertise, notably with consideration of several new systemic therapy options, such as targeted therapy and immuno-oncology approaches. These new treatments contribute to challenges within the third major domain of neuro-oncology, the diagnosis, treatment and prevention of nervous system toxicity of old and new anti-cancer treatments. All these considerations strongly argue for the development of specialised centres of excellence to improve care for patients with brain tumour across Europe.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Life Sciences > Cancer Research
Language:English
Date:June 2018
Deposited On:24 Oct 2018 15:04
Last Modified:29 Jul 2020 07:44
Publisher:Elsevier
ISSN:0959-8049
OA Status:Closed
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.ejca.2018.03.016
PubMed ID:29656021

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