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MalaQuick™ versus ParaSight F® as a diagnostic aid in travellers' malaria


Funk, Maia; Schlagenhauf, Patricia; Tschopp, Alois; Steffen, Robert (1999). MalaQuick™ versus ParaSight F® as a diagnostic aid in travellers' malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 93(3):268-272.

Abstract

In this study we assessed whether travellers can perform malaria rapid tests, following the provided information leaflet, and correctly interpret performed and pre-prepared test strips. Two Plasmodium falciparum testing systems, namely MalaQuick™ (ICT) and ParaSight F® were used. Test performance and test interpretation of pre-prepared tests were compared. There was no significant difference in test performance between the 2 tests. Interpretation of prepared test strips in both test systems was very reliable in blood parasite densities between 0·1% and 2%, but major problems were encountered at low parasitaemia (<0·1% blood parasites) and also in ParaSight F test strips showing high parasitaemia (>2% blood parasites). Low parasitaemia ParaSight F test strips were correctly interpreted by 52·1% compared with 10·8% correct interpretations with MalaQuick (P < 0·0001). Correct interpretation of highly positive (>2% blood parasites) pre-prepared test strips was higher with MalaQuick (96·8%) than with ParaSight F (33·8%), P < 0·0001. Both tests were associated with high levels of false-negative interpretations which render them unsuitable as self-diagnostic kits. Efforts must be made to assist lay individuals in test performance by technical test improvement, by equiping the test strips with an additional reading aid for interpretation, and by providing instruction by a skilled person

Abstract

In this study we assessed whether travellers can perform malaria rapid tests, following the provided information leaflet, and correctly interpret performed and pre-prepared test strips. Two Plasmodium falciparum testing systems, namely MalaQuick™ (ICT) and ParaSight F® were used. Test performance and test interpretation of pre-prepared tests were compared. There was no significant difference in test performance between the 2 tests. Interpretation of prepared test strips in both test systems was very reliable in blood parasite densities between 0·1% and 2%, but major problems were encountered at low parasitaemia (<0·1% blood parasites) and also in ParaSight F test strips showing high parasitaemia (>2% blood parasites). Low parasitaemia ParaSight F test strips were correctly interpreted by 52·1% compared with 10·8% correct interpretations with MalaQuick (P < 0·0001). Correct interpretation of highly positive (>2% blood parasites) pre-prepared test strips was higher with MalaQuick (96·8%) than with ParaSight F (33·8%), P < 0·0001. Both tests were associated with high levels of false-negative interpretations which render them unsuitable as self-diagnostic kits. Efforts must be made to assist lay individuals in test performance by technical test improvement, by equiping the test strips with an additional reading aid for interpretation, and by providing instruction by a skilled person

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:510 Mathematics
Uncontrolled Keywords:Public Health, Environmental and Occupational Health, Parasitology, Infectious Diseases, General Medicine
Language:English
Date:1 May 1999
Deposited On:19 Sep 2018 15:04
Last Modified:24 Nov 2018 02:52
Publisher:Elsevier
ISSN:0035-9203
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/s0035-9203(99)90018-4
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101016S0035920399900184 (Library Catalogue)

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