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Hereditary hydrocephalus internus in a laboratory strain of golden hamsters (Mesocricetus auratus)


Gebhardt-Henrich, S G; Edwards, J F; Famula, T R; Lipp, H-P; Steiger, A (2008). Hereditary hydrocephalus internus in a laboratory strain of golden hamsters (Mesocricetus auratus). Animal: The International Journal of Animal Biosciences, 2(9):1265-1272.

Abstract

Golden hamsters of one common laboratory strain had a high incidence of hydrocephalus internus. When a severity score of hydrocephalus was used, a major autosomal recessive locus could be identified. However, when a binary score (hydrocephalus, no hydrocephalus) was used, no such major locus could be detected and results of test matings were not consistent with Mendelian inheritance. Golden hamsters with severe forms of hydrocephalus had a dorsally compressed and ventrally intact hippocampus. Implications for the behavior and well-being of affected hamsters are unknown but researchers using this strain should be aware of the likely presence of hydrocephalus

Abstract

Golden hamsters of one common laboratory strain had a high incidence of hydrocephalus internus. When a severity score of hydrocephalus was used, a major autosomal recessive locus could be identified. However, when a binary score (hydrocephalus, no hydrocephalus) was used, no such major locus could be detected and results of test matings were not consistent with Mendelian inheritance. Golden hamsters with severe forms of hydrocephalus had a dorsally compressed and ventrally intact hippocampus. Implications for the behavior and well-being of affected hamsters are unknown but researchers using this strain should be aware of the likely presence of hydrocephalus

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Scopus Subject Areas:Life Sciences > Animal Science and Zoology
Language:English
Date:1 September 2008
Deposited On:11 Oct 2018 13:43
Last Modified:15 Apr 2021 14:47
Publisher:Cambridge University Press
ISSN:1751-7311
OA Status:Green
Publisher DOI:https://doi.org/10.1017/s1751731108002395
PubMed ID:22443814

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