Header

UZH-Logo

Maintenance Infos

Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum


Hebisch, Gundula; Neumaier-Wagner, Peruka M; Huch, Renate; von Mandach, Ursula (2004). Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum. Journal of Perinatal Medicine, 32(6):475-480.

Abstract

Aims: To measure maternal serum interleukins (IL) in pregnancy, delivery and early puerperium, and to identify their potential determinants. Methods: Prospective longitudinal measures of serum IL-1β, IL-6 and IL-8 in 38 healthy pregnant women at antenatal visits, through labor and delivery, with clinical correlates (infection, vaginal hemorrhage and anemia) recorded by questionnaire. Results: Pregnancy IL levels remained consistently low. IL-1β increased shortly before delivery, then returned to pregnant levels, except where blood loss exceeded 500 ml. IL-6 and IL-8 rose at labor onset and exceeded pregnancy levels through postpartum day three. Postpartum IL-6 was higher after non-elective cesarean section than after spontaneous delivery (P < 0.0001), and where blood loss exceeded 500 ml. IL-6 and IL-8 were higher with systemic infection during delivery (P < 0.0001) and on postpartum day one (P < 0.05); IL-8 was higher in anemia (delivery: P < 0.005; postpartum day 1: P < 0.05). Differences due to delivery mode and systemic infection remained significant after correction for other conditions. Conclusions: Labor-dependent inflammation increases all IL levels at delivery. Further studies with larger sample sizes are required to establish reference values differentiating physiology from pathology as an aid to peripartum management

Abstract

Aims: To measure maternal serum interleukins (IL) in pregnancy, delivery and early puerperium, and to identify their potential determinants. Methods: Prospective longitudinal measures of serum IL-1β, IL-6 and IL-8 in 38 healthy pregnant women at antenatal visits, through labor and delivery, with clinical correlates (infection, vaginal hemorrhage and anemia) recorded by questionnaire. Results: Pregnancy IL levels remained consistently low. IL-1β increased shortly before delivery, then returned to pregnant levels, except where blood loss exceeded 500 ml. IL-6 and IL-8 rose at labor onset and exceeded pregnancy levels through postpartum day three. Postpartum IL-6 was higher after non-elective cesarean section than after spontaneous delivery (P < 0.0001), and where blood loss exceeded 500 ml. IL-6 and IL-8 were higher with systemic infection during delivery (P < 0.0001) and on postpartum day one (P < 0.05); IL-8 was higher in anemia (delivery: P < 0.005; postpartum day 1: P < 0.05). Differences due to delivery mode and systemic infection remained significant after correction for other conditions. Conclusions: Labor-dependent inflammation increases all IL levels at delivery. Further studies with larger sample sizes are required to establish reference values differentiating physiology from pathology as an aid to peripartum management

Statistics

Citations

Dimensions.ai Metrics
36 citations in Web of Science®
36 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

31 downloads since deposited on 11 Oct 2018
14 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pediatrics, Perinatology and Child Health
Health Sciences > Obstetrics and Gynecology
Language:English
Date:4 January 2004
Deposited On:11 Oct 2018 17:39
Last Modified:31 Jul 2020 01:57
Publisher:De Gruyter
ISSN:0300-5577
OA Status:Green
Publisher DOI:https://doi.org/10.1515/jpm.2004.131
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencegruyter101515JPM2004131 (Library Catalogue)
PubMed ID:15576267

Download

Green Open Access

Download PDF  'Maternal serum interleukin-1β, -6 and -8 levels and potential determinants in pregnancy and peripartum'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 169kB
View at publisher