Header

UZH-Logo

Maintenance Infos

Lycopene and myocardial infarction risk in the EURAMIC study


Kohlmeier, L; Kark, J D; Gomez-Gracia, E; Martin, B C; Steck, S E; Kardinaal, A F M; Ringstad, J; Thamm, M; Masaev, V; Riemersma, R; Martin-Moreno, J M; Huttunen, J K; Kok, F J (1997). Lycopene and myocardial infarction risk in the EURAMIC study. American Journal of Epidemiology, 146(8):618-626.

Abstract

A multicenter case-control study was conducted to evaluate the relations between antioxidant status assessed by biomarkers and acute myocardial infarction. Incidence cases and frequency matched controls were recruited from 10 European countries to maximize the variance in exposure within the study. Adipose tissue needle aspiration biopsies were taken shortly after the infarction and analyzed for levels of carotenoids and tocopherols. An examination of colinearity including all covariates and the three carotenoids, α-carotene, β-carotene, and lycopene, showed that the variables were sufficiently independent to model simultaneously. When examined singularly, each of the carotenoids appeared to be protective. Upon simultaneous analyses of the carotenoids, however, using conditional logistic regression models that controlled for age, body mass index, socioeconomic status, smoking, hypertension, and maternal and paternal history of disease, lycopene remained independently protective, with an odds ratio of 0.52 for the contrast of the 10th and 90th percentiles (95% confidence interval 0.33-0.82, p= 0.005). The associations for α- and β-carotene were largely eliminated. We conclude that lycopene, or some substance highly correlated which is in a common food source, may contribute to the protective effect of vegetable consumption on myocardial infarction risk

Abstract

A multicenter case-control study was conducted to evaluate the relations between antioxidant status assessed by biomarkers and acute myocardial infarction. Incidence cases and frequency matched controls were recruited from 10 European countries to maximize the variance in exposure within the study. Adipose tissue needle aspiration biopsies were taken shortly after the infarction and analyzed for levels of carotenoids and tocopherols. An examination of colinearity including all covariates and the three carotenoids, α-carotene, β-carotene, and lycopene, showed that the variables were sufficiently independent to model simultaneously. When examined singularly, each of the carotenoids appeared to be protective. Upon simultaneous analyses of the carotenoids, however, using conditional logistic regression models that controlled for age, body mass index, socioeconomic status, smoking, hypertension, and maternal and paternal history of disease, lycopene remained independently protective, with an odds ratio of 0.52 for the contrast of the 10th and 90th percentiles (95% confidence interval 0.33-0.82, p= 0.005). The associations for α- and β-carotene were largely eliminated. We conclude that lycopene, or some substance highly correlated which is in a common food source, may contribute to the protective effect of vegetable consumption on myocardial infarction risk

Statistics

Citations

Dimensions.ai Metrics
272 citations in Web of Science®
319 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

35 downloads since deposited on 15 Oct 2018
13 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Scopus Subject Areas:Health Sciences > Epidemiology
Language:English
Date:15 October 1997
Deposited On:15 Oct 2018 15:45
Last Modified:31 Jul 2020 01:59
Publisher:Oxford University Press
ISSN:0002-9262
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/oxfordjournals.aje.a009327
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093oxfordjournalsajea009327 (Library Catalogue)
PubMed ID:9345115

Download

Hybrid Open Access

Download PDF  'Lycopene and myocardial infarction risk in the EURAMIC study'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 778kB
View at publisher