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Ionized calcium in acidosis: differential effect of hypercapnic and lactic acidosis


Schaer, H; Bachmann, U (1974). Ionized calcium in acidosis: differential effect of hypercapnic and lactic acidosis. British Journal of Anaesthesia, 46(11):842-848.

Abstract

The effects of various forms of acidosis on ionized calcium concentrations were investigated in vivo in rabbits and in vitro in human plasma. Calculation of least square regression equations of ionized calcium (mM) on pH yielded the following regression coefficients in human plasma: hypercapnic acidosis —0.53±0.07; hydrochloric acidosis —0.65±0.06; lactic acidosis —0.27±0.05. These findings in human plasma are roughly paralleled by those in rabbits. From stability constants it was calculated that the formation of Ca-lactate complexes accounts for the difference between lactic and hydrochloric acidosis. It is concluded that differences in the behaviour of ionized calcium between hypercapnic and lactic acidosis might contribute to the known differences in cardiovascular effects

Abstract

The effects of various forms of acidosis on ionized calcium concentrations were investigated in vivo in rabbits and in vitro in human plasma. Calculation of least square regression equations of ionized calcium (mM) on pH yielded the following regression coefficients in human plasma: hypercapnic acidosis —0.53±0.07; hydrochloric acidosis —0.65±0.06; lactic acidosis —0.27±0.05. These findings in human plasma are roughly paralleled by those in rabbits. From stability constants it was calculated that the formation of Ca-lactate complexes accounts for the difference between lactic and hydrochloric acidosis. It is concluded that differences in the behaviour of ionized calcium between hypercapnic and lactic acidosis might contribute to the known differences in cardiovascular effects

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Anesthesiology and Pain Medicine
Language:English
Date:1 November 1974
Deposited On:15 Oct 2018 15:58
Last Modified:31 Jul 2020 01:59
Publisher:Elsevier
ISSN:0007-0912
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/bja/46.11.842
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093bja4611842 (Library Catalogue)
PubMed ID:4621213

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