Header

UZH-Logo

Maintenance Infos

Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen


Kempf, Werner; Adams, Volker; Mirandola, Prisco; Menotti, Laura; Di Luca, Dario; Wey, Norbert; Müller, Beatrix; Campadelli‐Fiume, Gabriella (1998). Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen. Journal of Infectious Diseases, 178(3):841-845.

Abstract

Human herpesvirus 7 (HHV-7) infection in histologically normal human tissues was investigated by immunohistochemical detection of the 85-kDa tegument phosphoprotein (pp85) encoded by the U14 gene. So far, two cell types were recognized as sites of HHV-7 infection in vivo: CD4+ T lymphocytes, believed to be the site of latent infection, and epithelial cells of salivary glands, the site of productive infection and viral shedding. Unexpectedly, cells expressing the HHV-7 structural antigen were detectable in lungs, skin, and mammary glands. Morphologically and phenotypically, they were distinct from lymphocytes. Liver, kidney, and tonsils were positive, although the number of HHV-7-positive cells was low. Large intestine, spleen, and brain were negative. Different from the current notion of the state of HHV-7 in humans, the results show that a variety of tissues harbor cells at a late stage of infection and suggest that HHV-7 causes a persistent rather than a true latent infection

Abstract

Human herpesvirus 7 (HHV-7) infection in histologically normal human tissues was investigated by immunohistochemical detection of the 85-kDa tegument phosphoprotein (pp85) encoded by the U14 gene. So far, two cell types were recognized as sites of HHV-7 infection in vivo: CD4+ T lymphocytes, believed to be the site of latent infection, and epithelial cells of salivary glands, the site of productive infection and viral shedding. Unexpectedly, cells expressing the HHV-7 structural antigen were detectable in lungs, skin, and mammary glands. Morphologically and phenotypically, they were distinct from lymphocytes. Liver, kidney, and tonsils were positive, although the number of HHV-7-positive cells was low. Large intestine, spleen, and brain were negative. Different from the current notion of the state of HHV-7 in humans, the results show that a variety of tissues harbor cells at a late stage of infection and suggest that HHV-7 causes a persistent rather than a true latent infection

Statistics

Citations

Dimensions.ai Metrics
44 citations in Web of Science®
59 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

6 downloads since deposited on 17 Oct 2018
6 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 September 1998
Deposited On:17 Oct 2018 15:14
Last Modified:24 Nov 2018 02:55
Publisher:Oxford University Press
ISSN:0022-1899
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1086/515339
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101086515339 (Library Catalogue)
PubMed ID:9728555

Download

Download PDF  'Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 192kB
View at publisher