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Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin


Kempf, W (2003). Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin. Carcinogenesis, 24(2):301-306.

Abstract

Primary cutaneous CD30-positive lymphoproliferative disorders (LPD) comprise a spectrum of disorders including lymphomatoid papulosis (LyP) and CD30+ pleomorphic or anaplastic large T-cell lymphomas ( 1 – 3 ). LyP is a chronic, recurrent lymphoproliferative disorder which manifests clinically as papulonodular, spontaneously regressing skin lesions ( 4 ). Histologically, large pleomorphic and anaplastic tumor cells are found which are activated T-lymphocytes expressing the CD30 antigen ( 5 , 6 ).
Viruses are known etiologic factors in the pathogenesis of non-Hodgkin’s lymphomas (NHL) ( 7 ). In particular, retroviruses such as human T-lymphotropic virus 1 and 2 (HTLV-1 and 2) have been linked to adult T-cell leukemia/lymphoma (ATLL) and other forms of NHL (for review see refs 8 and 9). Primary cutaneous lymphomas, especially cutaneous T-cell lymphomas, have been considered to be caused by viruses. Several reports of the detection of HTLV-1 or 2 sequences in cutaneous T-cell lymphomas (CTCL) ( 10 – 13 ) have not been confirmed in other studies ( 8 , 9 , 14 , 15 ).

Abstract

Primary cutaneous CD30-positive lymphoproliferative disorders (LPD) comprise a spectrum of disorders including lymphomatoid papulosis (LyP) and CD30+ pleomorphic or anaplastic large T-cell lymphomas ( 1 – 3 ). LyP is a chronic, recurrent lymphoproliferative disorder which manifests clinically as papulonodular, spontaneously regressing skin lesions ( 4 ). Histologically, large pleomorphic and anaplastic tumor cells are found which are activated T-lymphocytes expressing the CD30 antigen ( 5 , 6 ).
Viruses are known etiologic factors in the pathogenesis of non-Hodgkin’s lymphomas (NHL) ( 7 ). In particular, retroviruses such as human T-lymphotropic virus 1 and 2 (HTLV-1 and 2) have been linked to adult T-cell leukemia/lymphoma (ATLL) and other forms of NHL (for review see refs 8 and 9). Primary cutaneous lymphomas, especially cutaneous T-cell lymphomas, have been considered to be caused by viruses. Several reports of the detection of HTLV-1 or 2 sequences in cutaneous T-cell lymphomas (CTCL) ( 10 – 13 ) have not been confirmed in other studies ( 8 , 9 , 14 , 15 ).

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Cancer Research
Language:English
Date:1 February 2003
Deposited On:10 Oct 2018 09:58
Last Modified:31 Jul 2020 02:00
Publisher:Oxford University Press
ISSN:0143-3334
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/carcin/24.2.301
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093carcin242301 (Library Catalogue)

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