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Monographies on drugs, which are frequently analysed in the course of therapeutic drug monitoring


Rentsch, K; Fathi, M; Grignaschi, N; Magnin, J L; Printzen, G; Thormann, W; Wenk, M; Werner, D (2005). Monographies on drugs, which are frequently analysed in the course of therapeutic drug monitoring. Journal of Laboratory Medicine, 29(4):287-297.

Abstract

In 1995 the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) has already published a printed version of drug monographs, which are now newly compiled and presented in a standardised manner. The aim of these monographs is to give an overview on the most important informations that are necessary in order to request a drug analysis or is helpful to interpret the results. Therefore, the targeted audience are laboratory health professionals or the receivers of the reports. There is information provided on the indication for therapeutic drug monitoring, protein binding, metabolic pathways and enzymes involved, elimination half life time and elimination routes as well as information on therapeutic or toxic concentrations. Because preanalytical considerations are of particular importance for therapeutic drug monitoring, there is also information given at which time the determination of the drug concentration is reasonable and when steady-state concentrations are reached after changing the dose. Furthermore, the stability of the drug and its metabolite(s), respectively, after blood sampling is described. For readers with a specific interest, references to important publications are given. The number of the monographs will be continuously enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch). We hope that these monographs are helpful for you handling therapeutic drug monitoring and look forward to comments of the audience

Abstract

In 1995 the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) has already published a printed version of drug monographs, which are now newly compiled and presented in a standardised manner. The aim of these monographs is to give an overview on the most important informations that are necessary in order to request a drug analysis or is helpful to interpret the results. Therefore, the targeted audience are laboratory health professionals or the receivers of the reports. There is information provided on the indication for therapeutic drug monitoring, protein binding, metabolic pathways and enzymes involved, elimination half life time and elimination routes as well as information on therapeutic or toxic concentrations. Because preanalytical considerations are of particular importance for therapeutic drug monitoring, there is also information given at which time the determination of the drug concentration is reasonable and when steady-state concentrations are reached after changing the dose. Furthermore, the stability of the drug and its metabolite(s), respectively, after blood sampling is described. For readers with a specific interest, references to important publications are given. The number of the monographs will be continuously enlarged. The updated files are presented on the homepage of the SSCC (www.sscc.ch). We hope that these monographs are helpful for you handling therapeutic drug monitoring and look forward to comments of the audience

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Additional indexing

Other titles:Monographien über Medikamente, die regelmässig im Rahmen des Therapeutic Drug Monitorings analysiert werden
Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Scopus Subject Areas:Life Sciences > Clinical Biochemistry
Health Sciences > Medical Laboratory Technology
Health Sciences > Biochemistry (medical)
Language:English
Date:1 January 2005
Deposited On:19 Oct 2018 16:21
Last Modified:15 Apr 2021 14:48
Publisher:De Gruyter
ISSN:2567-9449
OA Status:Green
Publisher DOI:https://doi.org/10.1515/jlm.2005.040

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