Header

UZH-Logo

Maintenance Infos

Mouse skin papilloma formation by chronic dermal application of 7, 12-dimethylbenz[a] anthracene is not reduced by diet restriction


Fischer, Wolfgang H; Lutz, Werner K (1994). Mouse skin papilloma formation by chronic dermal application of 7, 12-dimethylbenz[a] anthracene is not reduced by diet restriction. Carcinogenesis, 15(1):129-131.

Abstract

Diet restriction has repeatedly been shown to reduce the incidence of spontaneous and chemically induced tumors in rodents. However, no conclusive data are available to show whether carcinogenesis by chronic exposure to a genotoxic agent can also be retarded. In this study, diet restriction to 70% was investigated for a protective effect on the formation of skin papilloma in male NMRI mice treated twice weekly with 20 nmol 7,12-dimethylbenz(a)anthracene (DMBA). Rather surprisingly, no protection was seen. Both time of onset of papilloma formation (13 weeks in both groups) and time of 50% cumulative incidence (t50; 17.5 and 18 weeks) were similar in the unrestricted and the restricted group. In contrast, a clearly protective elTect was found in mice initiated with 100 nmol DMBA and promoted twice weekly with 2.5 nmol 12-O-tetradecanoylphorbol-13-acetate: the onset of papilloma formation increased from 7 to 11.5 weeks, the t50 was shifted from 8.5 to 19 weeks. Diet restriction, therefore, was not protective under conditions of chronic exposure to a genotoxic carcinogen. It cannot be considered a universal measure of cancer prevention

Abstract

Diet restriction has repeatedly been shown to reduce the incidence of spontaneous and chemically induced tumors in rodents. However, no conclusive data are available to show whether carcinogenesis by chronic exposure to a genotoxic agent can also be retarded. In this study, diet restriction to 70% was investigated for a protective effect on the formation of skin papilloma in male NMRI mice treated twice weekly with 20 nmol 7,12-dimethylbenz(a)anthracene (DMBA). Rather surprisingly, no protection was seen. Both time of onset of papilloma formation (13 weeks in both groups) and time of 50% cumulative incidence (t50; 17.5 and 18 weeks) were similar in the unrestricted and the restricted group. In contrast, a clearly protective elTect was found in mice initiated with 100 nmol DMBA and promoted twice weekly with 2.5 nmol 12-O-tetradecanoylphorbol-13-acetate: the onset of papilloma formation increased from 7 to 11.5 weeks, the t50 was shifted from 8.5 to 19 weeks. Diet restriction, therefore, was not protective under conditions of chronic exposure to a genotoxic carcinogen. It cannot be considered a universal measure of cancer prevention

Statistics

Citations

Dimensions.ai Metrics
2 citations in Web of Science®
3 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

23 downloads since deposited on 12 Oct 2018
8 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Cancer Research
Language:English
Date:1 January 1994
Deposited On:12 Oct 2018 09:28
Last Modified:15 Apr 2021 14:48
Publisher:Oxford University Press
ISSN:0143-3334
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/carcin/15.1.129

Download

Green Open Access

Download PDF  'Mouse skin papilloma formation by chronic dermal application of 7, 12-dimethylbenz[a] anthracene is not reduced by diet restriction'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 280kB
View at publisher