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Nippostrongylus brasiliensis in the rat: failure to relate intestinal histamine and mast cell levels with worm expulsion


Keller, R (1971). Nippostrongylus brasiliensis in the rat: failure to relate intestinal histamine and mast cell levels with worm expulsion. Parasitology, 63(3):473-481.

Abstract

This paper describes experiments to determine whether intestinal tissue mast cells and/or intestinal histamine are involved in the second, expulsive step of worm elimination. In neonatal rats, intestinal tissue contains only very little histamine and mature mast cells are encountered only sporadically. From birth to the adult age, there was a gradual rise in both intestinal mast cells and histamine. During Nippostrongylus brasiliensis infection in the adult rat, the concentration of histamine in the small intestine was clearly lower than in uninfected controls.Especially low histamine values were found to occur on days 6-12 of a primary infection in the region where the main worm burden was located. Similarly, the number of tissue mast cells present in the epithelium of the jejunum was decreased in the same region and during the same period of time. From the observation that the bulk of the parasites are expelled at a time when histamme and mast cell levels are low, it was concluded that mast cells and their constituents were not an essential factor in the second step of worm elimination This work was supported by the Schweizerische Nationalfonds zur Förderung der wissenschaftlichen Forschung (Grant 5200.3). The skilful technical assistance of Miss I. Beeger, Miss R. Keist and Miss M. Iseli is gratefully acknowledged. I thank Mr H. Berchtold, Biostatistisches Zentrum der Universität Zürich, for the statistical evaluation of the data

Abstract

This paper describes experiments to determine whether intestinal tissue mast cells and/or intestinal histamine are involved in the second, expulsive step of worm elimination. In neonatal rats, intestinal tissue contains only very little histamine and mature mast cells are encountered only sporadically. From birth to the adult age, there was a gradual rise in both intestinal mast cells and histamine. During Nippostrongylus brasiliensis infection in the adult rat, the concentration of histamine in the small intestine was clearly lower than in uninfected controls.Especially low histamine values were found to occur on days 6-12 of a primary infection in the region where the main worm burden was located. Similarly, the number of tissue mast cells present in the epithelium of the jejunum was decreased in the same region and during the same period of time. From the observation that the bulk of the parasites are expelled at a time when histamme and mast cell levels are low, it was concluded that mast cells and their constituents were not an essential factor in the second step of worm elimination This work was supported by the Schweizerische Nationalfonds zur Förderung der wissenschaftlichen Forschung (Grant 5200.3). The skilful technical assistance of Miss I. Beeger, Miss R. Keist and Miss M. Iseli is gratefully acknowledged. I thank Mr H. Berchtold, Biostatistisches Zentrum der Universität Zürich, for the statistical evaluation of the data

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
600 Technology
Language:English
Date:1 December 1971
Deposited On:25 Oct 2018 14:53
Last Modified:24 Sep 2019 23:39
Publisher:Cambridge University Press
ISSN:0031-1820
OA Status:Green
Publisher DOI:https://doi.org/10.1017/s0031182000079993
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencecambridge101017S0031182000079993 (Library Catalogue)
PubMed ID:5139027

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