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Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age


Lücke, Thomas; Kanzelmeyer, Nele; Kemper, Markus J; Tsikas, Dimitrios; Das, Anibh M (2007). Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age. Clinical Chemistry and Laboratory Medicine, 45(11):1525-1530.

Abstract

Background: The L-arginine/nitric oxide (NO) pathway has multiple physiological functions including vasodilation, inhibition of platelet aggregation and neurotransmission. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of all known NO synthase isoforms, has adverse effects on renal and cardiovascular function in adults. It is unknown whether ADMA might also exert similar effects in younger individuals including infants. Also, reference data for important members of the L-arginine/NO family, notably ADMA and the NO metabolites, nitrite and nitrate, in infancy are lacking.
Methods: In the present study, we investigated the status of the L-arginine/NO pathway in 34 healthy volunteers aged 2 days to 24 years by measuring the concentration of ADMA, nitrite, nitrate and L-arginine in plasma and urine using gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry methods.
Results: We found that ADMA levels in plasma decreased with age (Pearson correlation coefficient r=–0.619, p<0.001). In contrast, urinary excretion of nitrate (r=0.471, p=0.036) and nitrite increased with age (r=0.484, p=0.037).
Conclusions: Our study suggests that in infants ADMA biosynthesis accompanied by an inhibition of NO synthesis is higher than in adults and diminishes considerably with age.

Abstract

Background: The L-arginine/nitric oxide (NO) pathway has multiple physiological functions including vasodilation, inhibition of platelet aggregation and neurotransmission. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of all known NO synthase isoforms, has adverse effects on renal and cardiovascular function in adults. It is unknown whether ADMA might also exert similar effects in younger individuals including infants. Also, reference data for important members of the L-arginine/NO family, notably ADMA and the NO metabolites, nitrite and nitrate, in infancy are lacking.
Methods: In the present study, we investigated the status of the L-arginine/NO pathway in 34 healthy volunteers aged 2 days to 24 years by measuring the concentration of ADMA, nitrite, nitrate and L-arginine in plasma and urine using gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry methods.
Results: We found that ADMA levels in plasma decreased with age (Pearson correlation coefficient r=–0.619, p<0.001). In contrast, urinary excretion of nitrate (r=0.471, p=0.036) and nitrite increased with age (r=0.484, p=0.037).
Conclusions: Our study suggests that in infants ADMA biosynthesis accompanied by an inhibition of NO synthesis is higher than in adults and diminishes considerably with age.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Uncontrolled Keywords:age-dependency; asymmetric dimethylarginine (ADMA); childhood; infancy; nitric oxide (NO); nitric oxide synthase (NOS)
Language:English
Date:1 January 2007
Deposited On:26 Oct 2018 16:37
Last Modified:31 Oct 2018 11:16
Publisher:De Gruyter
ISSN:1434-6621
OA Status:Green
Publisher DOI:https://doi.org/10.1515/cclm.2007.300
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencegruyter101515CCLM2007300 (Library Catalogue)

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