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Antibacterial properties of imipenem with special reference to the activity against methicillin-resistant staphylococci, cefotaxime-resistant Enterobacteriaceae and Pseudomonas aeruginosa


Vurma-Rapp, U; Kayser, F H; Barberis-Maino, L (1986). Antibacterial properties of imipenem with special reference to the activity against methicillin-resistant staphylococci, cefotaxime-resistant Enterobacteriaceae and Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy, 18(Supp.):27-33.

Abstract

Imipenem was examined with standardized agar dilution procedures against a wide range of bacteria. Geometric mean MICs against the genera Escherichia, Klebsiella, Enterobacter, Citrobacter and Serratia were 0·1-0·4 mg/1, and Proteus and Providencia spp. were inhibited by 0·25-4 mg/1. Acinetobacter calcoaceticus var. anitratum strains were inhibited by concentrations ranging from 0·12-0·5 mg/1. Methicillin-susceptible staphylococci were highly susceptible to the drug (MICs: ⩾0·03 mg/1) and enterococci were inhibited by 0·25-16 mg/1. Most of the multi-resistant JK corynebacteria were resistant to imipenem. Imipenem was more active than any other ß-lactam against methicillin-resistant staphylococci; this was also demonstrated in a population analysis. Imipenem-resistant minorities in populations, however, were also observed. Cefotaxime-resistant and -intermediate Enterobacter and Citrobacter strains were inhibited by concentrations of 0·5 mg/1 or less. No third-generation cephalosporin nor any other ß-lactam showed similarly high activity against these groups of organisms. Among 20 ceftazidime-resistant and 20 ceftazidime-susceptible isolates of Pseudomonas aeruginosa, no strain was resistant and only five ceftazidime-resistant strains were intermediately susceptible (MIC, 8 mg/1) to imipenem

Abstract

Imipenem was examined with standardized agar dilution procedures against a wide range of bacteria. Geometric mean MICs against the genera Escherichia, Klebsiella, Enterobacter, Citrobacter and Serratia were 0·1-0·4 mg/1, and Proteus and Providencia spp. were inhibited by 0·25-4 mg/1. Acinetobacter calcoaceticus var. anitratum strains were inhibited by concentrations ranging from 0·12-0·5 mg/1. Methicillin-susceptible staphylococci were highly susceptible to the drug (MICs: ⩾0·03 mg/1) and enterococci were inhibited by 0·25-16 mg/1. Most of the multi-resistant JK corynebacteria were resistant to imipenem. Imipenem was more active than any other ß-lactam against methicillin-resistant staphylococci; this was also demonstrated in a population analysis. Imipenem-resistant minorities in populations, however, were also observed. Cefotaxime-resistant and -intermediate Enterobacter and Citrobacter strains were inhibited by concentrations of 0·5 mg/1 or less. No third-generation cephalosporin nor any other ß-lactam showed similarly high activity against these groups of organisms. Among 20 ceftazidime-resistant and 20 ceftazidime-susceptible isolates of Pseudomonas aeruginosa, no strain was resistant and only five ceftazidime-resistant strains were intermediately susceptible (MIC, 8 mg/1) to imipenem

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 July 1986
Deposited On:18 Oct 2018 10:06
Last Modified:26 Oct 2018 14:24
Publisher:Oxford University Press
ISSN:0305-7453
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/jac/18.supplement_e.27
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093jac18Supplement_E27 (Library Catalogue)

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