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Long term accuracy of fluorescence polarization immunoassays for gentamicin, tobramycin, netilmicin and vancomycin


Joos, Beda; Lüthy, Ruedi; Blaser, Jürg (1989). Long term accuracy of fluorescence polarization immunoassays for gentamicin, tobramycin, netilmicin and vancomycin. Journal of Antimicrobial Chemotherapy, 24(5):797-803.

Abstract

External quality control was performed during six years to determine the accuracy over time of the Abbott TDx fluorescence polarization system for assaying antibiotics. Unknown spiked serum samples of gentamicin, tobramycin, netilmicin and vancomycin were provided monthly by the British national external quality assessment scheme. Comparison of the 209 assay results with the target concentrations showed good correlations in all four assays. No significant deviations from linearity, from slope 1·0, and from intercept 0·0 were detected by regression analysis. Relative deviations were <10% and <15% for 78% and 90% of all specimens, respectively. On an average the same calibration curves could be used over a period of 19 weeks . Fluorescence polarization immunoassays provided rapid and reliable results over the entire study period

Abstract

External quality control was performed during six years to determine the accuracy over time of the Abbott TDx fluorescence polarization system for assaying antibiotics. Unknown spiked serum samples of gentamicin, tobramycin, netilmicin and vancomycin were provided monthly by the British national external quality assessment scheme. Comparison of the 209 assay results with the target concentrations showed good correlations in all four assays. No significant deviations from linearity, from slope 1·0, and from intercept 0·0 were detected by regression analysis. Relative deviations were <10% and <15% for 78% and 90% of all specimens, respectively. On an average the same calibration curves could be used over a period of 19 weeks . Fluorescence polarization immunoassays provided rapid and reliable results over the entire study period

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 January 1989
Deposited On:17 Oct 2018 14:39
Last Modified:30 Oct 2018 09:48
Publisher:Oxford University Press
ISSN:0305-7453
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/jac/24.5.797
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093jac245797 (Library Catalogue)

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