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Effect of pO2 and pH on synergy of tazobactam and β-lactam antibiotics against β-lactamase producing Enterobacteriaceae


König, Christiane; Blaser, Jürg (1995). Effect of pO2 and pH on synergy of tazobactam and β-lactam antibiotics against β-lactamase producing Enterobacteriaceae. Journal of Antimicrobial Chemotherapy, 36(3):513-519.

Abstract

Synergy between tazobactam and ceftriaxone or piperacillin against β-lactamase producing Enterobacteriaceae was not influenced by the presence or absence of oxygen. For most strains synergy was excellent at neutral pH but reduced in acidic conditions. Low pH increased 50% of the MICs up to or beyond the sensitivity breakpoint

Abstract

Synergy between tazobactam and ceftriaxone or piperacillin against β-lactamase producing Enterobacteriaceae was not influenced by the presence or absence of oxygen. For most strains synergy was excellent at neutral pH but reduced in acidic conditions. Low pH increased 50% of the MICs up to or beyond the sensitivity breakpoint

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 January 1995
Deposited On:12 Oct 2018 07:40
Last Modified:24 Nov 2018 02:58
Publisher:Oxford University Press
ISSN:0305-7453
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/jac/36.3.513
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093jac363513 (Library Catalogue)

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