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Promotion of tumor growth in vivo by antimacrophage agents


Keller, R (1976). Promotion of tumor growth in vivo by antimacrophage agents. Journal of the National Cancer Institute, 57(6):1355-1361.

Abstract

Various attempts were made to assess the role of the mononuclear phagocyte system in tumor resistance of rats in vivo. The growth of sc inoculated, weakly immunogenic, carcinogen-induced, syngeneic tumor cells was modestly reduced by ip injection and, more impressively, by local injection of peptone-induced, activated, nonimmune macrophages. A single iv injection of silica particles or carrageenan on the day of sc tumor cell inoculation greatly enhanced tumor growth. When these agents had been given a few days before or after tumor cell inoculation, the tumor-promoting efficiency was distinctly diminished or even cancelled. The enhancing effects of silica and carrageenan on tumor growth were nullified by the macrophage-stabilizing agent, poly-2-vinylpyridine N-oxide. To assess the in vivo consequences of silica administration, various cellular, biochemical, and functional macrophage parameters were determined at different intervals. Results indicated the complexity of events elicited after the mononuclear phagocyte system was damaged, which made the interpretation of such results difficult

Abstract

Various attempts were made to assess the role of the mononuclear phagocyte system in tumor resistance of rats in vivo. The growth of sc inoculated, weakly immunogenic, carcinogen-induced, syngeneic tumor cells was modestly reduced by ip injection and, more impressively, by local injection of peptone-induced, activated, nonimmune macrophages. A single iv injection of silica particles or carrageenan on the day of sc tumor cell inoculation greatly enhanced tumor growth. When these agents had been given a few days before or after tumor cell inoculation, the tumor-promoting efficiency was distinctly diminished or even cancelled. The enhancing effects of silica and carrageenan on tumor growth were nullified by the macrophage-stabilizing agent, poly-2-vinylpyridine N-oxide. To assess the in vivo consequences of silica administration, various cellular, biochemical, and functional macrophage parameters were determined at different intervals. Results indicated the complexity of events elicited after the mononuclear phagocyte system was damaged, which made the interpretation of such results difficult

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Life Sciences > Cancer Research
Language:English
Date:1 December 1976
Deposited On:29 Oct 2018 15:17
Last Modified:31 Jul 2020 02:09
Publisher:Oxford University Press
ISSN:0027-8874
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/jnci/57.6.1355
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093jnci5761355 (Library Catalogue)
PubMed ID:187804

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