Header

UZH-Logo

Maintenance Infos

Impact of HIV‐1 reverse transcriptase polymorphism F214L on virological response to thymidine analogue–based regimens in antiretroviral therapy (ART)–naive and ART‐experienced patients


Ceccherini‐Silberstein, Francesca; Cozzi‐Lepri, Alessandro; Ruiz, Lidia; Mocroft, Amanda; Phillips, Andrew N; Olsen, Christian Holkmann; Gatell, Jose M; Günthard, Huldrych F; Reiss, Peter; Perno, Carlo Federico; Clotet, Bonaventura; Lundgren, Jens D (2007). Impact of HIV‐1 reverse transcriptase polymorphism F214L on virological response to thymidine analogue–based regimens in antiretroviral therapy (ART)–naive and ART‐experienced patients. Journal of Infectious Diseases, 196(8):1180-1190.

Abstract

Background.#160;A negative association between the polymorphism F214L and type 1 thymidine analogue (TA) mutations (TAMs) has been observed. However, the virological response to TAs according to the detection of F214L has not been evaluated. Methods.We studied 590 patients from EuroSIDA who started TA therapy for the first time as part of potent combination antiretroviral therapy (cART) and who were tested for genotypic resistance within the past 6 months. End points were median reduction in the week 24 viral load and time to virological failure (2 consecutive VL measurements >400 copies/mL after at least 6 months of the TA-containing cART). Results.In ART-naive patients, the prevalence of F214L was 17%. By 48 months after starting TA-based cART, the proportion of patients who experienced virological failure was 16% in patients with 214L and 36% in those with 214F (P = .03). In a multivariable Cox regression model, the relative hazard of virological failure for patients with 214L compared with those with 214F was 0.22 (95% confidence interval, 0.07—0.72). In ART-experienced patients, results were similar, and larger differences in virological response associated with the detection of 214L versus F were observed in patients with M41L/T215Y and mixed TAM profiles detected before the initiation of cART. Conclusions.This study provides evidence that the detection of polymorphism F214L is associated with a favorable virological response to TA-based cART

Abstract

Background.#160;A negative association between the polymorphism F214L and type 1 thymidine analogue (TA) mutations (TAMs) has been observed. However, the virological response to TAs according to the detection of F214L has not been evaluated. Methods.We studied 590 patients from EuroSIDA who started TA therapy for the first time as part of potent combination antiretroviral therapy (cART) and who were tested for genotypic resistance within the past 6 months. End points were median reduction in the week 24 viral load and time to virological failure (2 consecutive VL measurements >400 copies/mL after at least 6 months of the TA-containing cART). Results.In ART-naive patients, the prevalence of F214L was 17%. By 48 months after starting TA-based cART, the proportion of patients who experienced virological failure was 16% in patients with 214L and 36% in those with 214F (P = .03). In a multivariable Cox regression model, the relative hazard of virological failure for patients with 214L compared with those with 214F was 0.22 (95% confidence interval, 0.07—0.72). In ART-experienced patients, results were similar, and larger differences in virological response associated with the detection of 214L versus F were observed in patients with M41L/T215Y and mixed TAM profiles detected before the initiation of cART. Conclusions.This study provides evidence that the detection of polymorphism F214L is associated with a favorable virological response to TA-based cART

Statistics

Citations

Dimensions.ai Metrics
11 citations in Web of Science®
9 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 30 Oct 2018
8 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:15 October 2007
Deposited On:30 Oct 2018 17:53
Last Modified:04 Nov 2018 17:14
Publisher:Oxford University Press
ISSN:0022-1899
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1086/521678
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101086521678 (Library Catalogue)

Download

Download PDF  'Impact of HIV‐1 reverse transcriptase polymorphism F214L on virological response to thymidine analogue–based regimens in antiretroviral therapy (ART)–naive and ART‐experienced patients'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 263kB
View at publisher