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Improved cardiac performance with human calcitonin gene related peptide in patients with congestive heart failure


Gennari, C; Nami, R; Agnusdei, D; Fischer, J A (1990). Improved cardiac performance with human calcitonin gene related peptide in patients with congestive heart failure. Cardiovascular Research, 24(3):239-241.

Abstract

Study objective - The aim of the study was to assess the cardiovascular effects of human calcitonin gene related peptide (CGRP) in patients with congestive heart failure. Design - The effects of CGRP II (or β), 12.5 μg·h−1, given by intravenous infusion for 24 h to digitalised patients with congestive heart failure, were assessed by measurement of cardiac functional indices. Patients - Five patients (four female) were studied. Age was 73-82 years. Three were in New York Heart Association phase III and two in phase IV. Measurements and main results - The pre-ejection period to left ventricular ejection time ratio and the QT distance adjusted for heart rate were lowered by 21% and 4% respectively. The left ventricular shortening index was raised by 43%. The arterial pressure and heart rate did not change consistently. Conclusion - Calcitonin gene related peptide improves myocardial contractility in patients with congestive heart failure. This is the first time this has been shown

Abstract

Study objective - The aim of the study was to assess the cardiovascular effects of human calcitonin gene related peptide (CGRP) in patients with congestive heart failure. Design - The effects of CGRP II (or β), 12.5 μg·h−1, given by intravenous infusion for 24 h to digitalised patients with congestive heart failure, were assessed by measurement of cardiac functional indices. Patients - Five patients (four female) were studied. Age was 73-82 years. Three were in New York Heart Association phase III and two in phase IV. Measurements and main results - The pre-ejection period to left ventricular ejection time ratio and the QT distance adjusted for heart rate were lowered by 21% and 4% respectively. The left ventricular shortening index was raised by 43%. The arterial pressure and heart rate did not change consistently. Conclusion - Calcitonin gene related peptide improves myocardial contractility in patients with congestive heart failure. This is the first time this has been shown

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 March 1990
Deposited On:16 Oct 2018 15:34
Last Modified:24 Sep 2019 23:40
Publisher:Oxford University Press
ISSN:0008-6363
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/cvr/24.3.239
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093cvr243239 (Library Catalogue)

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