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Double-blind study of the reversal of midazolam-supplemented general anaesthesia with ro 15–1788


Alon, E; Baitella, L; Hossli, G (1987). Double-blind study of the reversal of midazolam-supplemented general anaesthesia with ro 15–1788. British Journal of Anaesthesia, 59(4):455-458.

Abstract

The actions and side effects of the benzodiaze-pine antagonist Ro 15-1788 were evaluated in a randomized double-blind clinical study in which midazolam was used as an anaesthetic agent. Sixty women who underwent laparoscopy were treated with Ro 15-1788 or with placebo after the surgical procedure. Ro 15-1788 reversed the hypnotic effect of midazolam within a few minutes. The patients were alert, co-operative, oriented and had good recall of events after awakening. The effects were statistically better than placebo for up to 30 min after administration. Arterial pressure and heart rate remained stable and there were no significant side effects. The availability of Ro 15-1788 allows effective reversal of midazolam when this is used during general anaesthesia

Abstract

The actions and side effects of the benzodiaze-pine antagonist Ro 15-1788 were evaluated in a randomized double-blind clinical study in which midazolam was used as an anaesthetic agent. Sixty women who underwent laparoscopy were treated with Ro 15-1788 or with placebo after the surgical procedure. Ro 15-1788 reversed the hypnotic effect of midazolam within a few minutes. The patients were alert, co-operative, oriented and had good recall of events after awakening. The effects were statistically better than placebo for up to 30 min after administration. Arterial pressure and heart rate remained stable and there were no significant side effects. The availability of Ro 15-1788 allows effective reversal of midazolam when this is used during general anaesthesia

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 April 1987
Deposited On:18 Oct 2018 09:44
Last Modified:24 Nov 2018 02:59
Publisher:Elsevier
ISSN:0007-0912
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/bja/59.4.455
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093bja594455 (Library Catalogue)

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