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Long-Term Administration of Calcium Acetate Efficiently Controls Severe Hyperphosphataemia in Haemodialysis Patients


Hess, B; Binswanger, U (1990). Long-Term Administration of Calcium Acetate Efficiently Controls Severe Hyperphosphataemia in Haemodialysis Patients. Nephrology, Dialysis, Transplantation, 5(8):630-632.

Abstract

In order to avoid aluminium toxicity, calciumcontaining phosphate binders have been used increasingly. Unfortunately, calcium carbonate and calcium citrate produce hypercalcaemia in a number of patients. New studies have shown that calcium acetate is promising in that it binds more phosphate than calcium carbonate at comparable doses. We tested calcium acetate in eight severely hyperphosphataemic patients (2.25 ± 0.08 mmol/l) on maintenance haemodialysis over 5 months. Serum phosphate decreased to 1.86 ± 0.06 mmol/l, but at the cost of an increase in serum calcium. However, the increment of serum calcium was always less than the respective decrease of serum phosphate, and hypercalcaemia—immediately reversible after dose reduction—only occurred once in two patients

Abstract

In order to avoid aluminium toxicity, calciumcontaining phosphate binders have been used increasingly. Unfortunately, calcium carbonate and calcium citrate produce hypercalcaemia in a number of patients. New studies have shown that calcium acetate is promising in that it binds more phosphate than calcium carbonate at comparable doses. We tested calcium acetate in eight severely hyperphosphataemic patients (2.25 ± 0.08 mmol/l) on maintenance haemodialysis over 5 months. Serum phosphate decreased to 1.86 ± 0.06 mmol/l, but at the cost of an increase in serum calcium. However, the increment of serum calcium was always less than the respective decrease of serum phosphate, and hypercalcaemia—immediately reversible after dose reduction—only occurred once in two patients

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:1 January 1990
Deposited On:16 Oct 2018 15:37
Last Modified:24 Sep 2019 23:41
Publisher:Oxford University Press
ISSN:0931-0509
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/ndt/5.8.630
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093ndt58630 (Library Catalogue)

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