Header

UZH-Logo

Maintenance Infos

Stimulation of erythropoietin in renal insufficiency by hypobaric hypoxia


Quick, J; et al (1992). Stimulation of erythropoietin in renal insufficiency by hypobaric hypoxia. Nephrology, Dialysis, Transplantation, 7(10):1002-1006.

Abstract

Patients with renal anaemia show inadequate levels of immunoreactive erythropoietin (Epo) related to the degree of anaemia. The purpose of our study is to compare the degree of stimulation of Epo by means of hypobaric hypoxia in normal controls and patients with renal anaemia. Baseline Epo concentrations were found to be 11.1±2.0 U/l in 10 healthy volunteers and 11.4±4.6 U/l in six patients with renal anaemia. After exposure to hypobaric hypoxia equivalent to 4560 m above sea level for a duration of 3.5 h, we observed a significant increase in serum Epo in healthy volunteers to 22.8±9.1 U/l (P<0.005), while there was no increase in patients with renal anaemia: 12.3±5.2 U/l (P<0.2). Our results show that in patients with renal anaemia serum Epo concentrations are comparable to those of normal controls, but inadequate in view of the concomitant degree of anaemia. Stimulation by acute hypobaric hypoxia was not possible in patients with renal insufficiency as opposed to normal controls. From these data it can be concluded that either Epo production is working at maximum capacity under baseline conditions, or an additional hybobaric stimulus is not able to influence a disturbed set point of the oxygen sensor regulating Epo synthesis

Abstract

Patients with renal anaemia show inadequate levels of immunoreactive erythropoietin (Epo) related to the degree of anaemia. The purpose of our study is to compare the degree of stimulation of Epo by means of hypobaric hypoxia in normal controls and patients with renal anaemia. Baseline Epo concentrations were found to be 11.1±2.0 U/l in 10 healthy volunteers and 11.4±4.6 U/l in six patients with renal anaemia. After exposure to hypobaric hypoxia equivalent to 4560 m above sea level for a duration of 3.5 h, we observed a significant increase in serum Epo in healthy volunteers to 22.8±9.1 U/l (P<0.005), while there was no increase in patients with renal anaemia: 12.3±5.2 U/l (P<0.2). Our results show that in patients with renal anaemia serum Epo concentrations are comparable to those of normal controls, but inadequate in view of the concomitant degree of anaemia. Stimulation by acute hypobaric hypoxia was not possible in patients with renal insufficiency as opposed to normal controls. From these data it can be concluded that either Epo production is working at maximum capacity under baseline conditions, or an additional hybobaric stimulus is not able to influence a disturbed set point of the oxygen sensor regulating Epo synthesis

Statistics

Citations

Dimensions.ai Metrics
8 citations in Web of Science®
9 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

19 downloads since deposited on 16 Oct 2018
8 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Health Sciences > Nephrology
Health Sciences > Transplantation
Language:English
Date:1 January 1992
Deposited On:16 Oct 2018 14:22
Last Modified:15 Apr 2021 14:49
Publisher:Oxford University Press
ISSN:0931-0509
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/ndt/7.10.1002

Download

Green Open Access

Download PDF  'Stimulation of erythropoietin in renal insufficiency by hypobaric hypoxia'.
Preview
Content: Published Version
Language: English
Filetype: PDF (Nationallizenz 142-005)
Size: 362kB
View at publisher