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Intravenous 1,25(OH)2 Vitamin D3 Therapy in Haemodialysis Patients: Evaluation of Direct and Calcium-Mediated Short-Term Effects on Serum Parathyroid Hormone Concentration


Probst, W; Fischer, J A; Binswanger, U (1990). Intravenous 1,25(OH)2 Vitamin D3 Therapy in Haemodialysis Patients: Evaluation of Direct and Calcium-Mediated Short-Term Effects on Serum Parathyroid Hormone Concentration. Nephrology, Dialysis, Transplantation, 5(6):457-460.

Abstract

Eleven patients on chronic haemodialysis treatment thrice weekly received 1 μg 1,25(OH)2D3 i.v. after each dialysis for 3 weeks. Phosphate binders were mainly CaCO3, supplemented in a few patients by moderate amounts of A1(OH)3. Ionised calcium was measured by ion-selective electrode, normal values being 1.28-1.42mmol/l. PTH was estimated by an N-terminalsensitive assay; normal values are <0.25μg/ml. Results before and after 1,25(OH)2D3 were: ionised calcium before haemodialysis, 1.19±0.12and 1.17±0.14; ionised calcium after haemodialysis, 1.33±0.07 and 1.30±0.09; PTH before haemodialysis, 1.39±0.71 and 1.38±0.69; PTH after haemodialysis, 0.64±0.22 and 0.60 ±0.17; Phosphate before haemodialysis, 1.85±0.48 and 2.18±0.43 (P<0.05). No change of PTH concentration and ionised calcium before and after haemodialysis treatment could be documented after i.v. 1,25(OH)2D3 treatment. Mild and severe hyperparathyroidism were indistinguishable. Increased serum calcium concentrations therefore appear to be required for the suppression of PTH secretion by i.v. 1,25(OH)2D3 therapy

Abstract

Eleven patients on chronic haemodialysis treatment thrice weekly received 1 μg 1,25(OH)2D3 i.v. after each dialysis for 3 weeks. Phosphate binders were mainly CaCO3, supplemented in a few patients by moderate amounts of A1(OH)3. Ionised calcium was measured by ion-selective electrode, normal values being 1.28-1.42mmol/l. PTH was estimated by an N-terminalsensitive assay; normal values are <0.25μg/ml. Results before and after 1,25(OH)2D3 were: ionised calcium before haemodialysis, 1.19±0.12and 1.17±0.14; ionised calcium after haemodialysis, 1.33±0.07 and 1.30±0.09; PTH before haemodialysis, 1.39±0.71 and 1.38±0.69; PTH after haemodialysis, 0.64±0.22 and 0.60 ±0.17; Phosphate before haemodialysis, 1.85±0.48 and 2.18±0.43 (P<0.05). No change of PTH concentration and ionised calcium before and after haemodialysis treatment could be documented after i.v. 1,25(OH)2D3 treatment. Mild and severe hyperparathyroidism were indistinguishable. Increased serum calcium concentrations therefore appear to be required for the suppression of PTH secretion by i.v. 1,25(OH)2D3 therapy

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:1 January 1990
Deposited On:16 Oct 2018 15:37
Last Modified:24 Sep 2019 23:41
Publisher:Oxford University Press
ISSN:0931-0509
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/ndt/5.6.457
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicenceoxford101093ndt56457 (Library Catalogue)

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