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Whiplash and Concussion: Similar Acute Changes in Middle-Latency SEPs


Zumsteg, Dominik; Wennberg, Richard; Gütling, Eva; Hess, Klaus (2006). Whiplash and Concussion: Similar Acute Changes in Middle-Latency SEPs. Canadian Journal of Neurological Sciences, 33(04):379-386.

Abstract

Objective:Middle-latency somatosensory evoked potentials (SEPs) following median nerve stimulation can provide a sensitive measure of cortical function. We sought to determine whether the mechanical forces of whiplash injury or concussion alter normal processing of middle-latency SEPs.</jats:sec><jats:sec id="S0317167100005333_abs2">Methods:In a cross-sectional pilot study 20 subjects with whiplash were investigated (50% between 0.5-2 months and 50% between 6-41 months post injury) and compared to 83 healthy subjects using a standard middle-latency SEP procedure. In a subsequent prospective study subjects with either acute whiplash (n=13) or Grade 3 concussion (n=16) were investigated within 48 hours and again three months post injury.</jats:sec><jats:sec id="S0317167100005333_abs3">Results:In the pilot study the middle-latency SEP component N60 was significantly increased in the ten subjects investigated within two months after whiplash. In contrast, the ten subjects examined more than six months after injury showed normal latencies. In the prospective study N60 latencies were increased after whiplash and concussion when tested within 48 hours of injury. At three months, latencies were improved though still significantly different from controls post whiplash and concussion.</jats:sec><jats:sec id="S0317167100005333_abs4">Conclusion:Both whiplash injury and concussion alter processing of the middle-latency SEP component N60 in the acute post traumatic period. The acute changes appear to normalize between three-six months post injury. The SEP similarities suggest that the overlapping clinical symptomatology post whiplash and concussion may reflect a similar underlying mechanism of rotational mild traumatic brain injury.</jats:sec>

Abstract

Objective:Middle-latency somatosensory evoked potentials (SEPs) following median nerve stimulation can provide a sensitive measure of cortical function. We sought to determine whether the mechanical forces of whiplash injury or concussion alter normal processing of middle-latency SEPs.</jats:sec><jats:sec id="S0317167100005333_abs2">Methods:In a cross-sectional pilot study 20 subjects with whiplash were investigated (50% between 0.5-2 months and 50% between 6-41 months post injury) and compared to 83 healthy subjects using a standard middle-latency SEP procedure. In a subsequent prospective study subjects with either acute whiplash (n=13) or Grade 3 concussion (n=16) were investigated within 48 hours and again three months post injury.</jats:sec><jats:sec id="S0317167100005333_abs3">Results:In the pilot study the middle-latency SEP component N60 was significantly increased in the ten subjects investigated within two months after whiplash. In contrast, the ten subjects examined more than six months after injury showed normal latencies. In the prospective study N60 latencies were increased after whiplash and concussion when tested within 48 hours of injury. At three months, latencies were improved though still significantly different from controls post whiplash and concussion.</jats:sec><jats:sec id="S0317167100005333_abs4">Conclusion:Both whiplash injury and concussion alter processing of the middle-latency SEP component N60 in the acute post traumatic period. The acute changes appear to normalize between three-six months post injury. The SEP similarities suggest that the overlapping clinical symptomatology post whiplash and concussion may reflect a similar underlying mechanism of rotational mild traumatic brain injury.</jats:sec>

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Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Language:English
Date:1 November 2006
Deposited On:01 Nov 2018 14:09
Last Modified:24 Sep 2019 23:41
Publisher:Cambridge University Press
ISSN:0317-1671
OA Status:Green
Publisher DOI:https://doi.org/10.1017/s0317167100005333
Related URLs:https://www.swissbib.ch/Search/Results?lookfor=nationallicencecambridge101017S0317167100005333 (Library Catalogue)

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