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Whiplash and Concussion: Similar Acute Changes in Middle-Latency SEPs

Zumsteg, Dominik; Wennberg, Richard; Gütling, Eva; Hess, Klaus (2006). Whiplash and Concussion: Similar Acute Changes in Middle-Latency SEPs. Canadian Journal of Neurological Sciences, 33(4):379-386.

Abstract

OBJECTIVE: Middle-latency somatosensory evoked potentials (SEPs) following median nerve stimulation can provide a sensitive measure of cortical function. We sought to determine whether the mechanical forces of whiplash injury or concussion alter normal processing of middle-latency SEPs.
METHODS: In a cross-sectional pilot study 20 subjects with whiplash were investigated (50% between 0.5-2 months and 50% between 6-41 months post injury) and compared to 83 healthy subjects using a standard middle-latency SEP procedure. In a subsequent prospective study subjects with either acute whiplash (n=13) or Grade 3 concussion (n=16) were investigated within 48 hours and again three months post injury.
RESULTS: In the pilot study the middle-latency SEP component N60 was significantly increased in the ten subjects investigated within two months after whiplash. In contrast, the ten subjects examined more than six months after injury showed normal latencies. In the prospective study N60 latencies were increased after whiplash and concussion when tested within 48 hours of injury. At three months, latencies were improved though still significantly different from controls post whiplash and concussion.
CONCLUSION: Both whiplash injury and concussion alter processing of the middle-latency SEP component N60 in the acute post traumatic period. The acute changes appear to normalize between three-six months post injury. The SEP similarities suggest that the overlapping clinical symptomatology post whiplash and concussion may reflect a similar underlying mechanism of rotational mild traumatic brain injury.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:National licences > 142-005
Dewey Decimal Classification:Unspecified
Scopus Subject Areas:Life Sciences > Neurology
Health Sciences > Neurology (clinical)
Language:English
Date:1 November 2006
Deposited On:01 Nov 2018 14:09
Last Modified:19 Oct 2024 01:39
Publisher:Cambridge University Press
ISSN:0317-1671
OA Status:Green
Publisher DOI:https://doi.org/10.1017/s0317167100005333
PubMed ID:17168163
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  • Language: English
  • Description: Nationallizenz 142-005

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